Co-expression network analysis prioritizes signaling pathways regulating liver regeneration after partial hepatectomy in rats

The liver has extraordinary powers of regeneration following partial hepatectomy (PH). Changes in gene expression levels play a key role in cell proliferation and differentiation during liver regeneration (LR). To understand the molecular mechanisms underlying LR, this study was designed to assess t...

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Bibliographic Details
Published in:Genetics and molecular research 2016-04, Vol.15 (2)
Main Authors: Zhou, Y, Xu, J C, Xu, C S
Format: Article
Language:English
Subjects:
Animals
Gene Regulatory Networks
Hepatectomy
Histones - genetics
Histones - metabolism
Interleukin-6 - genetics
Interleukin-6 - metabolism
Liver - metabolism
Liver - physiology
Liver - surgery
Liver Regeneration
Rats
Rats, Sprague-Dawley
Signal Transduction
Transcriptome
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Summary:The liver has extraordinary powers of regeneration following partial hepatectomy (PH). Changes in gene expression levels play a key role in cell proliferation and differentiation during liver regeneration (LR). To understand the molecular mechanisms underlying LR, this study was designed to assess the time-dependent changes in rat hepatic gene expression. We obtained a gene expression profile of rat LR with high temporal resolution. We then constructed gene co-expression networks of regenerating liver tissue and identified 13 LR-specific modules from 1772 differentially expressed genes, and prioritized signaling pathways that regulated LR after PH. The results indicated that adipocytokine signaling, histone acetylation, and IL-6-related pathways play an important role in LR. Co-expression network analysis provides novel insight into understanding the molecular mechanisms behind LR.
ISSN:1676-5680
1676-5680
DOI:10.4238/gmr.15027596