Toward anticancer gold-based compounds targeting PARP-1: a new case study

A new gold( iii ) complex bearing a 2-((2,2-bipyridin)-5-yl)-1 H -benzimidazol-4-carboxamide ligand has been synthesized and characterized for its biological properties in vitro . In addition to showing promising antiproliferative effects against human cancer cells, the compound potently and selecti...

Full description

Saved in:
Bibliographic Details
Published in:RSC advances 2016-01, Vol.6 (82), p.79147-79152
Main Authors: Citta, A, Scalcon, V, Gbel, P, Bertrand, B, Wenzel, M, Folda, A, Rigobello, M. P, Meggers, E, Casini, A
Format: Article
Language:English
Subjects:
Anticancer properties
Antiproliferatives
Biological properties
Disrupting
Fingers
Ligands
Proteins
Zinc
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new gold( iii ) complex bearing a 2-((2,2-bipyridin)-5-yl)-1 H -benzimidazol-4-carboxamide ligand has been synthesized and characterized for its biological properties in vitro . In addition to showing promising antiproliferative effects against human cancer cells, the compound potently and selectively inhibits the zinc finger protein PARP-1, with respect to the seleno-enzyme thioredoxin reductase. The results hold promise for the design of novel gold-based anticancer agents disrupting PARP-1 function and to be used in combination therapies. A new gold( iii ) complex bearing a 2-((2,2-bipyridin)-5-yl)-1 H -benzimidazol-4-carboxamide ligand has been synthesized and characterized for its biological properties in vitro .
ISSN:2046-2069
2046-2069
DOI:10.1039/c6ra11606j