Mycobacterium bovis infection in a horse with granulomatous enterocolitis

A 2-year-old dappled Percheron horse had a wasting condition that did not respond to antibiotic treatments and ultimately resulted in death. Thickening of the wall of the large colon and enlargement of the mesenteric lymph nodes were observed at postmortem examination, along with the presence of pin...

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Bibliographic Details
Published in:Journal of veterinary diagnostic investigation 2015-03, Vol.27 (2), p.203-205
Main Authors: Sarradell, Javier E., Alvarez, Julio, Biscia, Mariana, Zumarraga, Martin, Wunschmann, Arno, Armien, Anibal G., Perez, Andres M.
Format: Article
Language:English
Subjects:
Animals
DNA, Bacterial - analysis
Enterocolitis - complications
Enterocolitis - veterinary
Fatal Outcome
Horse Diseases - diagnosis
Horse Diseases - microbiology
Horse Diseases - pathology
Horses
Lymph Nodes - pathology
Lymphadenitis - complications
Lymphadenitis - veterinary
Mycobacterium bovis
Mycobacterium bovis - genetics
Mycobacterium bovis - isolation & purification
Mycobacterium Infections - complications
Mycobacterium Infections - diagnosis
Mycobacterium Infections - veterinary
Polymerase Chain Reaction - veterinary
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Summary:A 2-year-old dappled Percheron horse had a wasting condition that did not respond to antibiotic treatments and ultimately resulted in death. Thickening of the wall of the large colon and enlargement of the mesenteric lymph nodes were observed at postmortem examination, along with the presence of pinpoint whitish foci in the liver. Microscopic examination of affected tissues revealed diffuse chronic granulomatous enterocolitis, granulomatous mesenteric lymphadenitis, and multifocal granulomatous hepatitis. The DNA extracted from paraffin-embedded intestinal and lymph node samples was analyzed using both a polymerase chain reaction (PCR) assay and PCR–restriction endonuclease analysis and demonstrated the presence of Mycobacterium bovis.
ISSN:1040-6387
1943-4936
DOI:10.1177/1040638715571359