Pro-Cognitive Effects of Non-Peptide Analogues of Soluble Amyloid Peptide Precursor Fragment sAPP

We studied pro-cognitive effect of two heterocyclic low-molecular-weight compounds that serve as non-peptide analogues of soluble fragment of amyloid peptide precursor (sAPP). Intracerebroventricular and systemic administration of peptide mimetics P2 and P5 improved weak memory on the model of passi...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2016-08, Vol.161 (4), p.447-450
Main Authors: Tiunova, A. A., Komissarova, N. V., Nenaidenko, V. G., Makhmutova, A. A., Beznosko, B. K., Bachurin, S. O., Anokhin, K. V.
Format: Article
Language:English
Subjects:
Amyloid beta-Peptides - chemistry
Amyloid beta-Peptides - pharmacology
Analysis
Animals
Behavior, Animal - drug effects
Biomedical and Life Sciences
Biomedicine
Cell Biology
Chickens
Cognition - drug effects
Internal Medicine
Laboratory Medicine
Male
Mice
Nootropic agents
Pathology
Peptide Fragments - chemistry
Peptide Fragments - pharmacology
Peptides
Physiology
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Summary:We studied pro-cognitive effect of two heterocyclic low-molecular-weight compounds that serve as non-peptide analogues of soluble fragment of amyloid peptide precursor (sAPP). Intracerebroventricular and systemic administration of peptide mimetics P2 and P5 improved weak memory on the model of passive avoidance in chicks and in the object location task in mice. Both compounds were effective if administered close to the moment of training or 4 h after it. The time windows and dose range for the pro-cognitive effects of the mimetics were similar to those observed in previous studies with sAPP peptide fragments.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3435-x