Linear scleroderma with prominent multiple lymphadenopathy followed by the development of polymyositis: A case report and review of published work

Localized scleroderma is an inflammatory disorder affecting the skin and underlying tissues, a certain subset of which develops other autoimmune diseases on the basis of a prominent autoimmune background. We here report a unique case of linear scleroderma presenting with a sclerotic plaque on the le...

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Bibliographic Details
Published in:Journal of dermatology 2016-10, Vol.43 (10), p.1224-1227
Main Authors: Takahashi, Takehiro, Asano, Yoshihide, Hirakawa, Maiko, Nakamura, Kouki, Saigusa, Ryosuke, Aozasa, Naohiko, Sumida, Hayakazu, Fujita, Hideki, Sugaya, Makoto, Ohmori, Aki, Shimizu, Jun, Sato, Shinichi
Format: Article
Language:English
Subjects:
Autoantibodies - blood
Autoimmune Diseases - diagnostic imaging
Autoimmune Diseases - drug therapy
Autoimmune Diseases - immunology
Autoimmune Diseases - pathology
Centrioles - immunology
Electromyography
Fascia - diagnostic imaging
Fascia - pathology
Female
Glucocorticoids - therapeutic use
Hepatomegaly - diagnostic imaging
Hepatomegaly - immunology
hepatosplenomegaly
Humans
immune abnormality
linear scleroderma
Lymph Nodes - pathology
lymphadenopathy
Lymphadenopathy - diagnostic imaging
Lymphadenopathy - drug therapy
Lymphadenopathy - immunology
Lymphadenopathy - pathology
Lymphedema - diagnostic imaging
Lymphedema - immunology
Magnetic Resonance Imaging
Middle Aged
Muscle, Skeletal - diagnostic imaging
Muscle, Skeletal - enzymology
Muscle, Skeletal - pathology
polymyositis
Polymyositis - diagnostic imaging
Polymyositis - drug therapy
Polymyositis - immunology
Polymyositis - pathology
Prednisolone - therapeutic use
Scleroderma
Scleroderma, Localized - diagnostic imaging
Scleroderma, Localized - drug therapy
Scleroderma, Localized - immunology
Scleroderma, Localized - pathology
Skin - pathology
Splenomegaly - diagnostic imaging
Splenomegaly - immunology
Tomography, X-Ray Computed
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Description
Summary:Localized scleroderma is an inflammatory disorder affecting the skin and underlying tissues, a certain subset of which develops other autoimmune diseases on the basis of a prominent autoimmune background. We here report a unique case of linear scleroderma presenting with a sclerotic plaque on the left thigh, multiple lymphadenopathy in bilateral inguinal and para‐aortic lymph nodes, and hepatosplenomegaly, who later developed polymyositis. We describe the detailed disease course of our case and discuss the clinical significance of multiple lymphadenopathy in localized scleroderma based on a review of published work.
ISSN:0385-2407
1346-8138
DOI:10.1111/1346-8138.13424