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Evaluating genotoxic risks in Brazilian public health agents occupationally exposed to pesticides: a multi-biomarker approach
This is the first study demonstrating genotoxic effects and whole transcriptome analysis on community health agents (CHAs) occupationally exposed to pesticides in Central Brazil. For the transcriptome analysis, we found some genes related to Alzheimer’s disease ( LRP1 ), an insulin-like growth facto...
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Published in: | Environmental science and pollution research international 2016-10, Vol.23 (19), p.19723-19734 |
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Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | This is the first study demonstrating genotoxic effects and whole transcriptome analysis on community health agents (CHAs) occupationally exposed to pesticides in Central Brazil. For the transcriptome analysis, we found some genes related to Alzheimer’s disease (
LRP1
), an insulin-like growth factor receptor (
IGF2R
), immunity genes (
IGL
family and
IGJ
), two genes related to inflammatory reaction (
CXCL5
and
CCL3
), one gene related to maintenance of cellular morphology (
NHS
), one gene considered to be a strong apoptosis inductor (
LGALS14
), and several transcripts of the neuroblastoma breakpoint family (
NBPF
). Related to comet assay, we demonstrated a significant increase in DNA damage, measured by the olive tail moment (OTM), in the exposed group compared to the control group. Moreover, we also observed a statistically significant difference in OTM values depending on GSTM1 genotypes. Therefore, Brazilian epidemiological surveillance, an organization responsible for the assessment and management of health risks associated to pesticide exposure to CHA, needs to be more proactive and considers the implications of pesticide exposure for CHA procedures and processes. |
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ISSN: | 0944-1344 1614-7499 |
DOI: | 10.1007/s11356-016-7179-y |