Relationship between glycemic control and coronary artery disease severity, prevalence and plaque characteristics by computed tomography coronary angiography in asymptomatic type 2 diabetic patients

• Published in: International Journal of Cardiovascular Imaging 2016-10, Vol.32 (10), p.1577-1585
• Main Authors: Tavares, C. A. F., Rassi, C. H. R. E., Fahel, M. G., Wajchenberg, B. L., Rochitte, C. E., Lerario, A. C.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Asymptomatic Diseases; Biomarkers - blood; Blood Glucose - metabolism; Brazil - epidemiology; Cardiac Imaging; Cardiology; Computed Tomography Angiography; Coronary Angiography - methods; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - epidemiology; Coronary Vessels - diagnostic imaging; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - epidemiology; Diabetic Angiopathies - diagnostic imaging; Diabetic Angiopathies - epidemiology; Female; Glycated Hemoglobin A - metabolism; Humans; Imaging; Male; Medicine; Medicine & Public Health; Middle Aged; Multidetector Computed Tomography; Original Paper; Plaque, Atherosclerotic; Predictive Value of Tests; Prevalence; Prognosis; Prospective Studies; Radiology; Risk Factors; Severity of Illness Index; Vascular Calcification - diagnostic imaging; Vascular Calcification - epidemiology; Vascular Remodeling
• ISSN: 1569-5794; 1573-0743; 1875-8312
• DOI: 10.1007/s10554-016-0942-9

Evaluate whether glycemic control in type 2 diabetes (DM2) asymptomatic for coronary artery disease (CAD) affects not only the presence and magnitude of CAD but also the characteristics of plaque vulnerability using multidetector row computed coronary tomography (MDCT). Acute coronary syndrome (ACS) is frequently observed in asymptomatic DM2 patients. Positive vessel remodeling (PR) and low-attenuation plaques (LAP) identified by MDCT have been demonstrated to be characteristics of subsequent culprit lesions of ACS. However, little is known regarding plaque characteristics in asymptomatic diabetic patients and their relationship with glycemic control. Ninety asymptomatic DM2 patients, aged 40–65 years old, underwent MDCT. The presence of atherosclerotic obstruction, defined as coronary stenosis ≥50 %, and plaque characteristics were compared between two groups of patients with A1c