Effect of 2,3,7,8-tetrachlorodibenzo- p-dioxin on trace elements, inflammation and viral clearance in the myocardium during Coxsackievirus B3 infection in mice

A myocarditic coxsackievirus B3 (CB3) infection in adult male A/J mice was used to investigate the effects of 2,3,7,8-tetrachlorodibenzo- para-dioxin (TCDD) exposure on mortality and on inflammatory lesion, virus and trace element contents of the heart. The mice were injected with four weekly intrap...

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Bibliographic Details
Published in:The Science of the total environment 2002-02, Vol.284 (1), p.135-147
Main Authors: Funseth, Eva, Wesslén, Lars, Lindh, Ulf, Friman, Göran, Ilbäck, Nils-Gunnar
Format: Article
Language:English
Subjects:
2,3,7,8-Tetrachlorodibenzo- p-dioxin
Animals
Biological and medical sciences
Calcium - chemistry
Chemical and industrial products toxicology. Toxic occupational diseases
Coxsackievirus B3
Coxsackievirus Infections - complications
Coxsackievirus Infections - immunology
Environmental Pollutants - adverse effects
Host resistance
Inflammation
Injections, Intraperitoneal
Male
Medical sciences
Mice
Myocardium - chemistry
Myocardium - pathology
Polychlorinated Dibenzodioxins - administration & dosage
Polychlorinated Dibenzodioxins - toxicity
RNA, Viral
Selenium - chemistry
Teratogens - toxicity
Toxicology
Trace elements
Trace Elements - analysis
Various organic compounds
Viral infection
Virus Replication
Zinc - analysis
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Summary:A myocarditic coxsackievirus B3 (CB3) infection in adult male A/J mice was used to investigate the effects of 2,3,7,8-tetrachlorodibenzo- para-dioxin (TCDD) exposure on mortality and on inflammatory lesion, virus and trace element contents of the heart. The mice were injected with four weekly intraperitoneal (i.p.) injections of TCDD (a loading dose of 5 μg/kg followed by three maintenance doses of 1.4 μg/kg). To reach a steady-state body burden of TCDD the mice were allowed a 90-day recovery period before infection with CB3 virus. TCDD increased the infection-induced mortality rate, whereas in TCDD-exposed mice, heart lesions at day 7 after the virus inoculation (median value 0.67% of the tissue section area; interquartile range 0.28; not statistically significant) were one-third of that in non-exposed infected mice (2.07% of the tissue section area; interquartile range 3.06). The size of the inflammatory heart lesion correlated to the amount of virus ( r s=0.829, P
ISSN:0048-9697
1879-1026
DOI:10.1016/S0048-9697(01)00874-9