Detection of oxidative species and low-molecular-weight DNA in skin following dermal exposure with JP-8 jet fuel

Dermal absorption of JP‐8 jet fuel can lead to skin irritation within hours after exposure. This study detected the formation of oxidative species and low‐molecular‐weight DNA in rat skin as potential indicators of JP‐8‐induced skin injury. At 0, 1, 2, 4 and 6 h after the beginning of a 1‐h exposure...

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Bibliographic Details
Published in:Journal of applied toxicology 2001-11, Vol.21 (6), p.521-525
Main Authors: Rogers, James V., Gunasekar, Palur G., Garrett, Carol M., Kabbur, Mahendra B., McDougal, James N.
Format: Article
Language:English
Subjects:
Absorption
Administration, Cutaneous
Aircraft
Animals
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
DNA Damage
DNA fragmentation
Hydrocarbons - adverse effects
Hydrocarbons - pharmacokinetics
Hydrocarbons - toxicity
JP-8 jet fuel
Kerosene - adverse effects
Male
Medical sciences
oxidative species
Rats
Rats, Inbred F344
Reactive Oxygen Species - analysis
skin
Skin - pathology
Toxicology
Various organic compounds
Volatilization
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Summary:Dermal absorption of JP‐8 jet fuel can lead to skin irritation within hours after exposure. This study detected the formation of oxidative species and low‐molecular‐weight DNA in rat skin as potential indicators of JP‐8‐induced skin injury. At 0, 1, 2, 4 and 6 h after the beginning of a 1‐h exposure, skin samples were removed and analyzed for oxidative species formation and low‐molecular‐weight DNA analysis. At 1, 2 and 4 h, mean oxidative species levels increased significantly (P < 0.05) above unexposed samples. Significantly higher (P < 0.05) low‐molecular‐weight DNA values were observed at 4 and 6 h compared with unexposed controls. These results demonstrate significant increases in oxidative species and low‐molecular‐weight DNA levels in the skin following dermal exposure to JP‐8. These responses may serve as indicators of skin injury following exposure to JP‐8 jet fuel and other volatile chemicals or mixtures. Copyright © 2001 John Wiley & Sons, Ltd.
ISSN:0260-437X
1099-1263
DOI:10.1002/jat.799