Cytogenetic studies on Nigella sativa seeds extract and thymoquinone on mouse cells infected with schistosomiasis using karyotyping

The protective effect of Nigella sativa seed extract and its main constituents thymoquinone (TQ) was studied on mouse cells infected with schistosomiasis. Bone marrow cells in the in vivo experiments and spleen cells in the in vitro one were used to evaluate the potentially protective effect of thes...

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Bibliographic Details
Published in:Mutation research. Genetic toxicology and environmental mutagenesis 2002-04, Vol.516 (1), p.11-17
Main Author: Aboul-Ela, Ezzat I.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bone marrow
Diseases caused by trematodes
Helminthic diseases
Infectious diseases
Karyotype
Medical sciences
Nigella sativa
Parasitic diseases
Schistosomiases
Schistosomiasis
Spleen
Thymoquinone
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Summary:The protective effect of Nigella sativa seed extract and its main constituents thymoquinone (TQ) was studied on mouse cells infected with schistosomiasis. Bone marrow cells in the in vivo experiments and spleen cells in the in vitro one were used to evaluate the potentially protective effect of these natural compounds on the induction of chromosomal aberrations. Karyotyping of the mice cells illustrated that the main abnormalities were gaps, fragments and deletions especially in chromosomes 2, 6 and some in chromosomes 13 and 14. Both N. sativa extract and TQ were considered as protective agents against the chromosomal aberrations induced as a result of schistosomiasis.
ISSN:1383-5718
1879-3592
DOI:10.1016/S1383-5718(01)00333-3