Cross-Reactive Antibodies Prevent the Lethal Effects of Staphylococcus aureus Superantigens

The exotoxins produced by Staphylococcus aureus, staphylococcal enterotoxins (SE) A-E and toxic shock syndrome toxin (TSST)-1, which are associated with serious diseases, including food poisoning and toxic shock syndrome, are termed superantigens (SAgs). To examine whether common antigenic epitopes...

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Bibliographic Details
Published in:The Journal of infectious diseases 1999-10, Vol.180 (4), p.1365-1369
Main Authors: Bavari, Sina, Ulrich, Robert G., LeClaire, Ross D.
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antibodies, Bacterial - blood
Antibody Formation
Bacterial diseases
Bacterial Toxins
Bacteriology
Biological and medical sciences
Concise Communications
Cross Reactions
Dosage
Enterotoxins - immunology
Experimental bacterial diseases and models
Fundamental and applied biological sciences. Psychology
Infectious diseases
Injections
Lipopolysaccharides - immunology
Medical sciences
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Microbiology
Specific Pathogen-Free Organisms
Staphylococcus
Staphylococcus aureus
Staphylococcus aureus - immunology
Superantigens
Superantigens - immunology
T lymphocytes
Toxicity
Toxins
Vaccination
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
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Summary:The exotoxins produced by Staphylococcus aureus, staphylococcal enterotoxins (SE) A-E and toxic shock syndrome toxin (TSST)-1, which are associated with serious diseases, including food poisoning and toxic shock syndrome, are termed superantigens (SAgs). To examine whether common antigenic epitopes were present and whether vaccination with 1 bacterial SAg could protect against challenge with a different SE or TSST-1, mice were vaccinated with SEA, SEB, SEC1, or TSST-1 individually or in combination. Mice injected with a single toxin developed high antibody titers against other SAgs. Marked improvement in survival was observed when immunized mice were challenged with a heterologous toxin. Mice vaccinated with a mixture of toxins were fully protected against 1 or multiple toxin challenges, indicating no interference effects of multivalent vaccinations. More importantly, higher titers were found against each SAg with the multivalent vaccination than with injection with a single SAg. Thus, immunizations with 1 SAg can induce cross-protective antibodies to heterologous SAgs, and multicomponent vaccination can enhance antibody responses against each bacterial SAg.
ISSN:0022-1899
1537-6613
DOI:10.1086/314977