In vivo micronucleus assays on 2,4-dichlorophenoxyacetic acid and its derivatives

The potential for 2,4-D and seven of its salts and esters to induce cytogenetic abnormalities in mammalian cells in vivo was investigated in the mouse bone marrow micronucleus test. All the test materials were administered to male and female mice by oral gavage and the frequencies of micronucleated...

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Bibliographic Details
Published in:Mutation research. Genetic toxicology and environmental mutagenesis 1999-07, Vol.444 (1), p.227-234
Main Authors: Charles, Jeffrey M, Cunny, Helen C, Wilson, Ronald D, Ivett, James L, Murli, Hema, Bus, James S, Gollapudi, Bhaskar
Format: Article
Language:English
Subjects:
2,4-dichlorophenoxyacetic acid
Biological and medical sciences
Medical sciences
Pesticides, fertilizers and other agrochemicals toxicology
Toxicology
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Summary:The potential for 2,4-D and seven of its salts and esters to induce cytogenetic abnormalities in mammalian cells in vivo was investigated in the mouse bone marrow micronucleus test. All the test materials were administered to male and female mice by oral gavage and the frequencies of micronucleated polychromatic erythrocytes (MN-PCE) in the bone marrow were determined at intervals of 24, 48 and 72 h following dosing. There were no significant increases in the incidence of MN-PCE in the treated mice at any of the bone marrow sampling times. These results are consistent with the reported lack of in vitro genetic toxicity for these materials in various in vitro genotoxicity assays as well as the absence of carcinogenic potential for 2,4-D in both mice and rats.
ISSN:1383-5718
1879-3592
DOI:10.1016/S1383-5718(99)00076-5