Pseudomonas aeruginosa: arsenal of resistance mechanisms, decades of changing resistance profiles, and future antimicrobial therapies

Antimicrobial resistance is one of the most serious public health issues facing humans since the discovery of antimicrobial agents. The frequent, prolonged, and uncontrolled use of antimicrobial agents are major factors in the emergence of antimicrobial-resistant bacterial strains, including multidr...

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Bibliographic Details
Published in:Future microbiology 2015-10, Vol.10 (10), p.1683-1706
Main Authors: El Zowalaty, Mohamed E, Al Thani, Asmaa A, Webster, Thomas J, El Zowalaty, Ahmed E, Schweizer, Herbert P, Nasrallah, Gheyath K, Marei, Hany E, Ashour, Hossam M
Format: Article
Language:English
Subjects:
Aminoglycosides - pharmacology
Anti-Bacterial Agents - pharmacology
Antibiotic resistance
Antibiotics
Antimicrobial agents
Antimicrobial resistance
Bacteria
beta-Lactam Resistance - genetics
beta-Lactamases - genetics
Biological Transport
Cell division
Cross Infection - microbiology
Drug resistance
Drug Resistance, Multiple, Bacterial - genetics
Drug therapy
Forecasts and trends
Genomes
Humans
Infections
Metabolism
Microbial drug resistance
Microbial Sensitivity Tests
Mortality
Multidrug resistance
Nanoparticles
Nanotechnology
Nosocomial infection
Pathogenesis
Pathogens
Phages
Precision medicine
Proteins
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
Pseudomonas aeruginosa - pathogenicity
Pseudomonas aeruginosa infections
Pseudomonas Infections - drug therapy
Pseudomonas Infections - microbiology
Public health
R&D
Research & development
RNA polymerase
Silicon nitride
Titanium
Vaccines
Viruses
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Summary:Antimicrobial resistance is one of the most serious public health issues facing humans since the discovery of antimicrobial agents. The frequent, prolonged, and uncontrolled use of antimicrobial agents are major factors in the emergence of antimicrobial-resistant bacterial strains, including multidrug-resistant variants. Pseudomonas aeruginosa is a leading cause of nosocomial infections. The abundant data on the increased resistance to antipseudomonal agents support the need for global action. There is a paucity of new classes of antibiotics active against P. aeruginosa. Here, we discuss recent antibacterial resistance profiles and mechanisms of resistance by P. aeruginosa. We also review future potential methods for controlling antibiotic-resistant bacteria, such as phage therapy, nanotechnology and antipseudomonal vaccines.
ISSN:1746-0913
1746-0921
DOI:10.2217/fmb.15.48