Endoscopic Features and Eosinophil Density Are Associated with Food Impaction in Adults with Esophageal Eosinophilia

Background and Aims Food impaction has been described in both eosinophilic esophagitis and proton pump inhibitor-responsive esophageal eosinophilia. The association between endoscopic/histologic features of esophageal eosinophilia and food impaction remains unclear. We aimed to identify clinical, en...

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Bibliographic Details
Published in:Digestive diseases and sciences 2016-09, Vol.61 (9), p.2578-2584
Main Authors: Mangla, Shikha, Goldin, Alison H., Singal, Gaurav, Hornick, Jason L., Hsu Blatman, Karen S., Burakoff, Robert, Chan, Walter W.
Format: Article
Language:English
Subjects:
Abdominal Pain - epidemiology
Abdominal Pain - etiology
Adult
Adults
Biochemistry
Cell Count
Cohort Studies
Comorbidity
Deglutition disorders
Deglutition Disorders - epidemiology
Deglutition Disorders - etiology
Endoscopy
Eosinophilia
Eosinophilic Esophagitis - complications
Eosinophilic Esophagitis - epidemiology
Eosinophilic Esophagitis - pathology
Eosinophils - pathology
Esophageal Stenosis - epidemiology
Esophageal Stenosis - etiology
Esophageal Stenosis - pathology
Esophagoscopy
Female
Gastroenterology
Heartburn - epidemiology
Heartburn - etiology
Hepatology
Humans
Logistic Models
Male
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Middle Aged
Oncology
Original Article
Retrospective Studies
Transplant Surgery
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Summary:Background and Aims Food impaction has been described in both eosinophilic esophagitis and proton pump inhibitor-responsive esophageal eosinophilia. The association between endoscopic/histologic features of esophageal eosinophilia and food impaction remains unclear. We aimed to identify clinical, endoscopic, and histologic findings associated with a history of food impaction in esophageal eosinophilia. Methods This was a retrospective cohort study of adult esophageal eosinophilia patients at a tertiary center in 6/2005–10/2014. Only patients with ≥15 eosinophils/high-power field on mucosal biopsies were included. Demographics, comorbidities, symptoms, endoscopic/histologic findings on initial endoscopy, and history of food impaction were reviewed. Statistical analyses were performed using Fisher’s exact test (univariate) and forward stepwise logistic regression (multivariate). Results 400 patients (42 ± 14 years, 61 % male) were included, with 78 (20 %) having food impaction history. On univariate analyses, rings (62 vs 42 %, p  = 0.003), erosions (12 vs 5 %, p  = 0.03), eosinophil density on biopsy (40 [IQR = 30–50] vs 30 [IQR = 15–50], p  = 0.004), and dysphagia (88 vs 62 %, p  
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-016-4190-6