Meniere's disease: histopathology, cytochemistry, and imaging

Meniere's disease is a poorly understood, disabling syndrome causing spells of vertigo, hearing fluctuation, tinnitus, and aural fullness. In this paper, we present a review of the histopathology, cytochemistry, and imaging of Meniere's disease. Histopathology is significant for neuroepith...

Full description

Saved in:
Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2015-04, Vol.1343 (1), p.49-57
Main Authors: Ishiyama, Gail, Lopez, Ivan A., Sepahdari, Ali R., Ishiyama, Akira
Format: Article
Language:English
Subjects:
Animals
aquaporins
Aquaporins - metabolism
endolymphatic hydrops
Histopathology
Humans
inner ear
Medical research
Meniere disease
Meniere Disease - metabolism
Meniere Disease - pathology
Meniere's disease
MRI imaging
vestibular
Vestibule, Labyrinth - metabolism
Vestibule, Labyrinth - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Meniere's disease is a poorly understood, disabling syndrome causing spells of vertigo, hearing fluctuation, tinnitus, and aural fullness. In this paper, we present a review of the histopathology, cytochemistry, and imaging of Meniere's disease. Histopathology is significant for neuroepithelial damage with hair cell loss, basement membrane thickening, and perivascular microvascular damage. Cytochemical alterations are significant for altered AQP4 and AQP6 expression in the supporting cell, and altered cochlin and mitochondrial protein expression. Current developments include imaging techniques to determine the degree and presence of endolymphatic hydrops, and future studies will endeavor to correlate the observance of hydrops with clinical findings.
ISSN:0077-8923
1749-6632
DOI:10.1111/nyas.12699