Carbendazim-induced haematological, biochemical and histopathological changes to the liver and kidney of male rats

• Published in: Human & experimental toxicology 2001-12, Vol.20 (12), p.625-630
• Main Authors: Selmanoğlu, G, Barlas, N, Songür, S, Koçskaya, E A
• Format: Article
• Language: English
• Subjects: Administration, Oral; Air Pollutants, Occupational - toxicity; Animals; Benzimidazoles - administration & dosage; Benzimidazoles - toxicity; Biological and medical sciences; Blood; Carbamates; carbendazim; Clinical Chemistry Tests; Creatinine; Diet; Dose-Response Relationship, Drug; Drinking water; Enzymes; Experiments; Fungicides; Hematologic Tests; Hematology; Hemoglobin; Kidney - drug effects; Kidney - pathology; Leukocytes; Liver; Liver - drug effects; Liver - pathology; Male; Medical sciences; Organ Size - drug effects; Pathogens; Pesticides; Pesticides, fertilizers and other agrochemicals toxicology; Random Allocation; Rats; Rats, Wistar; Rattus rattus; Toxicity Tests; Toxicology
• ISSN: 0960-3271; 1477-0903
• DOI: 10.1191/096032701718890603

Carbendazim is a systemic broad-spectrum fungicide controlling a wide range of pathogens. It is also used as a preservative in paint, textile, papermaking and leather industry, as well as a preservative of fruits. In the present study, carbendazim was administered at 0, 150, 300 and 600 mg/kg per day doses orally to male rats (Rattus rattus) for 15 weeks. At the end of the experiment, blood samples, liver and kidney tissues of each animal were taken. Serum enzyme activities, and haematological and biochemical parameters were analysed. In toxicological tests, 600 mg/kg per day doses of carbendazim caused an increase of albumin, glucose, creatinine and cholesterol levels. Also, at the same doses, white blood cell and lymphocyte counts decreased. However, mean cell hemoglobin and mean cell hemoglobin concentrations increased. Histopathological examinations revealed congestion, an enlargement of the sinusoids, an increase in the number of Kupffer cells, mononuclear cell infiltration and hydropic degeneration in the liver. At the highest doses, congestion, mononuclear cell infiltration, tubular degeneration and fibrosis were observed in the kidney tissue. These results indicate that 300 and 600 mg/kg per day carbendazim affected the liver and kidney tissue and caused some changes on haematological and biochemical parameters of rats.