The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients

This is the fifth in a series of safety evaluations performed by the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA). In 1993, the Panel initiated a comprehensive program to re-evaluate the safety of more than 1700 GRAS flavoring substances under conditions of intended use. E...

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Bibliographic Details
Published in:Food and Chemical Toxicology 2002-04, Vol.40 (4), p.429-451
Main Authors: Adams, T.B, Doull, J, Feron, V.J, Goodman, J.I, Marnett, L.J, Munro, I.C, Newberne, P.M, Portoghese, P.S, Smith, R.L, Waddell, W.J, Wagner, B.M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Flavoring agents
Food safety
Food toxicology
GRAS
Medical sciences
pyrazine
Pyrazine derivatives
Toxicology
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Summary:This is the fifth in a series of safety evaluations performed by the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA). In 1993, the Panel initiated a comprehensive program to re-evaluate the safety of more than 1700 GRAS flavoring substances under conditions of intended use. Elements that are fundamental to the safety evaluation of flavor ingredients include exposure, structural analogy, metabolism, pharmacokinetics and toxicology. Flavor ingredients are evaluated individually taking into account the available scientific information on the group of structurally related substances. Scientific data relevant to the safety evaluation of the use of pyrazine derivatives as flavoring ingredients is evaluated.
ISSN:0278-6915
1873-6351
DOI:10.1016/S0278-6915(01)00123-5