Human enteric viruses in Coquina clams associated with a large hepatitis A outbreak

An outbreak of hepatitis A, affecting 183 people, occurred in Valencia (Spain). Epidemiological evidence pointed to an association of the outbreak with consumption of Coquina clams (Donax sp), imported frozen from Peru. Shellfish were analysed for the presence of hepatitis A virus (HAV), enterovirus...

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Bibliographic Details
Published in:Water science and technology 2001-01, Vol.43 (12), p.61-65
Main Authors: Bosch, A, Sánchez, G, Le Guyader, F, Vanaclocha, H, Haugarreau, L, Pintó, R M
Format: Article
Language:English
Subjects:
Clams
Disease Outbreaks
DNA, Viral - analysis
Donax
Epidemiologic Studies
Epidemiology
Food Contamination
Fragments
Genomes
Genotypes
Hepatitis
Hepatitis A
Hepatitis A - epidemiology
Hepatitis A - transmission
Hepatitis A virus
Humans
Outbreaks
Peru
Reverse Transcriptase Polymerase Chain Reaction
Shellfish
Shellfish - virology
Spain - epidemiology
Spain, Valencia
Vira
Viruses
VP1 protein
VP1/2A protein
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Summary:An outbreak of hepatitis A, affecting 183 people, occurred in Valencia (Spain). Epidemiological evidence pointed to an association of the outbreak with consumption of Coquina clams (Donax sp), imported frozen from Peru. Shellfish were analysed for the presence of hepatitis A virus (HAV), enteroviruses, rotaviruses, astroviruses, caliciviruses and hepatitis E virus. HAV was detected in 75% of assayed shellfish samples. Other enteric viruses were occasionally found in the same samples. Molecular epidemiological analysis of fragments of the VP1/2A and the 5' end of the genome from shellfish and sera isolates, revealed the presence of six variants belonging to a single genotype.
ISSN:0273-1223
1996-9732
DOI:10.2166/wst.2001.0712