Splenic Granulomatous Lesions in Immunocompetent Pediatric Patients with Visceral Leishmaniasis

Visceral focal lesions are rarely encountered in patients with leishmaniasis despite the fact that splenomegaly, and to a lesser extent hepatomegaly, predominate among the clinical features of the disease. We present, using high resolution ultrasonography, the first 3 reported cases of focal splenic...

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Bibliographic Details
Published in:Scandinavian journal of infectious diseases 2001, Vol.33 (11), p.865-867
Main Author: Andrew Fretzayas, Maria Moustaki, Sofia Kitsiou, John Mathioudakis, Themistocles Karpathios
Format: Article
Language:English
Subjects:
antileishmanial agents
Antiprotozoal Agents - therapeutic use
Biological and medical sciences
Child
Child, Preschool
Granuloma - parasitology
Human protozoal diseases
Humans
Immunocompetence
Infant
Infectious diseases
Leishmania
Leishmaniasis, Visceral - complications
Leishmaniasis, Visceral - diagnosis
Leishmaniasis, Visceral - drug therapy
Leshmaniasis
Male
Medical sciences
Meglumine - therapeutic use
Meglumine Antimoniate
Organometallic Compounds - therapeutic use
Parasitic diseases
Prognosis
Protozoal diseases
Splenic Diseases - parasitology
Treatment Outcome
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Summary:Visceral focal lesions are rarely encountered in patients with leishmaniasis despite the fact that splenomegaly, and to a lesser extent hepatomegaly, predominate among the clinical features of the disease. We present, using high resolution ultrasonography, the first 3 reported cases of focal splenic involvement in immunocompetent children with visceral leishmaniasis. All patients showed a prompt response to the conventional anti-leishmanial treatment administered. This favorable outcome indicates that localized splenic lesions should not be considered as a poor prognostic factor and that alteration of the standard anti-leishmanial regimens is not justified.
ISSN:0036-5548
1651-1980
DOI:10.1080/00365540110027141