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Borage oil reduction of rheumatoid arthritis activity may be mediated by increased cAMP that suppresses tumor necrosis factor-alpha
Recent double blind studies have shown some benefit of borage oil in treatment of rheumatoid arthritis. Tumor necrosis factor-alpha has been shown to be a central mediator of inflammatory and joint destructive processes in rheumatoid arthritis. In this paper, evidence from published research is revi...
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| Published in: | International immunopharmacology 2001-11, Vol.1 (12), p.2197-2199 |
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| container_end_page | 2199 |
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| container_title | International immunopharmacology |
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| creator | Kast, Richard E |
| description | Recent double blind studies have shown some benefit of borage oil in treatment of rheumatoid arthritis. Tumor necrosis factor-alpha has been shown to be a central mediator of inflammatory and joint destructive processes in rheumatoid arthritis. In this paper, evidence from published research is reviewed that indicates gamma linolenic acid component of borage oil increases prostaglandin E levels that increase cAMP levels that in turn suppress tumor necrosis factor-alpha synthesis. If this biochemical path of borage oil is correct then (1) concomitant non-steroidal anti-inflammatory drug use would tend to undermine borage oil effects, and (2) borage oil would be contraindicated in pregnancy given the teratogenic and labor inducing effects of prostaglandin E agonists. |
| doi_str_mv | 10.1016/S1567-5769(01)00146-1 |
| format | article |
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Tumor necrosis factor-alpha has been shown to be a central mediator of inflammatory and joint destructive processes in rheumatoid arthritis. In this paper, evidence from published research is reviewed that indicates gamma linolenic acid component of borage oil increases prostaglandin E levels that increase cAMP levels that in turn suppress tumor necrosis factor-alpha synthesis. If this biochemical path of borage oil is correct then (1) concomitant non-steroidal anti-inflammatory drug use would tend to undermine borage oil effects, and (2) borage oil would be contraindicated in pregnancy given the teratogenic and labor inducing effects of prostaglandin E agonists.</description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/S1567-5769(01)00146-1</identifier><identifier>PMID: 11710548</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Abortion, Spontaneous - chemically induced ; Alprostadil - biosynthesis ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Antirheumatic Agents - adverse effects ; Antirheumatic Agents - pharmacology ; Antirheumatic Agents - therapeutic use ; Arthritis, Rheumatoid - drug therapy ; Biological and medical sciences ; Borage oil ; Borago - chemistry ; Borago officinalis ; Contraindications ; Cyclic adenosine monophosphate ; cyclic AMP ; Cyclic AMP - physiology ; Dinoprostone - biosynthesis ; Diseases of the osteoarticular system ; Double-Blind Method ; Drug Interactions ; Female ; gamma-Linolenic Acid - pharmacology ; gamma-Linolenic Acid - therapeutic use ; Humans ; Immunomodulators ; Inflammation ; Inflammatory joint diseases ; Medical sciences ; Pharmacology. Drug treatments ; Phytotherapy ; Plant Oils - adverse effects ; Plant Oils - pharmacology ; Plant Oils - therapeutic use ; Pregnancy ; Prostaglandin E ; Randomized Controlled Trials as Topic ; Rheumatoid arthritis ; Second Messenger Systems - drug effects ; Tumor Necrosis Factor-alpha - antagonists & inhibitors ; Tumor Necrosis Factor-alpha - biosynthesis ; Tumor necrosis-alpha</subject><ispartof>International immunopharmacology, 2001-11, Vol.1 (12), p.2197-2199</ispartof><rights>2001</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-92323fc7ae86aca2a5afbd83c257fcfe521a036f43d2df4c3621ae11b625c1903</citedby><cites>FETCH-LOGICAL-c422t-92323fc7ae86aca2a5afbd83c257fcfe521a036f43d2df4c3621ae11b625c1903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14073887$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11710548$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kast, Richard E</creatorcontrib><title>Borage oil reduction of rheumatoid arthritis activity may be mediated by increased cAMP that suppresses tumor necrosis factor-alpha</title><title>International immunopharmacology</title><addtitle>Int Immunopharmacol</addtitle><description>Recent double blind studies have shown some benefit of borage oil in treatment of rheumatoid arthritis. Tumor necrosis factor-alpha has been shown to be a central mediator of inflammatory and joint destructive processes in rheumatoid arthritis. In this paper, evidence from published research is reviewed that indicates gamma linolenic acid component of borage oil increases prostaglandin E levels that increase cAMP levels that in turn suppress tumor necrosis factor-alpha synthesis. If this biochemical path of borage oil is correct then (1) concomitant non-steroidal anti-inflammatory drug use would tend to undermine borage oil effects, and (2) borage oil would be contraindicated in pregnancy given the teratogenic and labor inducing effects of prostaglandin E agonists.</description><subject>Abortion, Spontaneous - chemically induced</subject><subject>Alprostadil - biosynthesis</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Antirheumatic Agents - adverse effects</subject><subject>Antirheumatic Agents - pharmacology</subject><subject>Antirheumatic Agents - therapeutic use</subject><subject>Arthritis, Rheumatoid - drug therapy</subject><subject>Biological and medical sciences</subject><subject>Borage oil</subject><subject>Borago - chemistry</subject><subject>Borago officinalis</subject><subject>Contraindications</subject><subject>Cyclic adenosine monophosphate</subject><subject>cyclic AMP</subject><subject>Cyclic AMP - physiology</subject><subject>Dinoprostone - biosynthesis</subject><subject>Diseases of the osteoarticular system</subject><subject>Double-Blind Method</subject><subject>Drug Interactions</subject><subject>Female</subject><subject>gamma-Linolenic Acid - pharmacology</subject><subject>gamma-Linolenic Acid - therapeutic use</subject><subject>Humans</subject><subject>Immunomodulators</subject><subject>Inflammation</subject><subject>Inflammatory joint diseases</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytotherapy</subject><subject>Plant Oils - adverse effects</subject><subject>Plant Oils - pharmacology</subject><subject>Plant Oils - therapeutic use</subject><subject>Pregnancy</subject><subject>Prostaglandin E</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Rheumatoid arthritis</subject><subject>Second Messenger Systems - drug effects</subject><subject>Tumor Necrosis Factor-alpha - antagonists & inhibitors</subject><subject>Tumor Necrosis Factor-alpha - biosynthesis</subject><subject>Tumor necrosis-alpha</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqFkE1v1DAQhiMEoh_wE0C-gMoh4LHjOHtCpeJLKgIJOFsTZ8waJXFqO5X2zB_H213UIyePPc-8Hj1V9Qz4a-DQvvkOqtW10u3mgsMrzqFpa3hQnUKnuxo0Vw9L_Q85qc5S-l0gzRt4XJ0AaOCq6U6rP-9CxF_Egh9ZpGG12YeZBcfiltYJc_ADw5i30WefGJb2rc87NuGO9cQmGjxmGli_Y362kTCVi7388o3lLWaW1mWJlBIlltcpRDaTjSGVJFeiQqxxXLb4pHrkcEz09HieVz8_vP9x9am-_vrx89XldW0bIXK9EVJIZzVS16JFgQpdP3TSCqWddaQEIJeta-QgBtdY2ZYHAuhboSxsuDyvXh5ylxhuVkrZTD5ZGkecKazJQCebVjZ7UB3A_bIpkjNL9BPGnQFu9vbNnX2zV2s4mDv7Bsrc8-MHa1_U3E8ddRfgxRHAZHF0EWfr0z3XcC27Thfu7YGjouPWUzTJeppt0R3JZjME_59V_gKRsqQC</recordid><startdate>20011101</startdate><enddate>20011101</enddate><creator>Kast, Richard E</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20011101</creationdate><title>Borage oil reduction of rheumatoid arthritis activity may be mediated by increased cAMP that suppresses tumor necrosis factor-alpha</title><author>Kast, Richard E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-92323fc7ae86aca2a5afbd83c257fcfe521a036f43d2df4c3621ae11b625c1903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Abortion, Spontaneous - chemically induced</topic><topic>Alprostadil - biosynthesis</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Antirheumatic Agents - adverse effects</topic><topic>Antirheumatic Agents - pharmacology</topic><topic>Antirheumatic Agents - therapeutic use</topic><topic>Arthritis, Rheumatoid - drug therapy</topic><topic>Biological and medical sciences</topic><topic>Borage oil</topic><topic>Borago - chemistry</topic><topic>Borago officinalis</topic><topic>Contraindications</topic><topic>Cyclic adenosine monophosphate</topic><topic>cyclic AMP</topic><topic>Cyclic AMP - physiology</topic><topic>Dinoprostone - biosynthesis</topic><topic>Diseases of the osteoarticular system</topic><topic>Double-Blind Method</topic><topic>Drug Interactions</topic><topic>Female</topic><topic>gamma-Linolenic Acid - pharmacology</topic><topic>gamma-Linolenic Acid - therapeutic use</topic><topic>Humans</topic><topic>Immunomodulators</topic><topic>Inflammation</topic><topic>Inflammatory joint diseases</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytotherapy</topic><topic>Plant Oils - adverse effects</topic><topic>Plant Oils - pharmacology</topic><topic>Plant Oils - therapeutic use</topic><topic>Pregnancy</topic><topic>Prostaglandin E</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Rheumatoid arthritis</topic><topic>Second Messenger Systems - drug effects</topic><topic>Tumor Necrosis Factor-alpha - antagonists & inhibitors</topic><topic>Tumor Necrosis Factor-alpha - biosynthesis</topic><topic>Tumor necrosis-alpha</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kast, Richard E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kast, Richard E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Borage oil reduction of rheumatoid arthritis activity may be mediated by increased cAMP that suppresses tumor necrosis factor-alpha</atitle><jtitle>International immunopharmacology</jtitle><addtitle>Int Immunopharmacol</addtitle><date>2001-11-01</date><risdate>2001</risdate><volume>1</volume><issue>12</issue><spage>2197</spage><epage>2199</epage><pages>2197-2199</pages><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract>Recent double blind studies have shown some benefit of borage oil in treatment of rheumatoid arthritis. Tumor necrosis factor-alpha has been shown to be a central mediator of inflammatory and joint destructive processes in rheumatoid arthritis. In this paper, evidence from published research is reviewed that indicates gamma linolenic acid component of borage oil increases prostaglandin E levels that increase cAMP levels that in turn suppress tumor necrosis factor-alpha synthesis. If this biochemical path of borage oil is correct then (1) concomitant non-steroidal anti-inflammatory drug use would tend to undermine borage oil effects, and (2) borage oil would be contraindicated in pregnancy given the teratogenic and labor inducing effects of prostaglandin E agonists.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>11710548</pmid><doi>10.1016/S1567-5769(01)00146-1</doi><tpages>3</tpages></addata></record> |
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| subjects | Abortion, Spontaneous - chemically induced Alprostadil - biosynthesis Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antirheumatic Agents - adverse effects Antirheumatic Agents - pharmacology Antirheumatic Agents - therapeutic use Arthritis, Rheumatoid - drug therapy Biological and medical sciences Borage oil Borago - chemistry Borago officinalis Contraindications Cyclic adenosine monophosphate cyclic AMP Cyclic AMP - physiology Dinoprostone - biosynthesis Diseases of the osteoarticular system Double-Blind Method Drug Interactions Female gamma-Linolenic Acid - pharmacology gamma-Linolenic Acid - therapeutic use Humans Immunomodulators Inflammation Inflammatory joint diseases Medical sciences Pharmacology. Drug treatments Phytotherapy Plant Oils - adverse effects Plant Oils - pharmacology Plant Oils - therapeutic use Pregnancy Prostaglandin E Randomized Controlled Trials as Topic Rheumatoid arthritis Second Messenger Systems - drug effects Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - biosynthesis Tumor necrosis-alpha |
| title | Borage oil reduction of rheumatoid arthritis activity may be mediated by increased cAMP that suppresses tumor necrosis factor-alpha |
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