Rates and predictors of relapse in first-episode non-affective psychosis: a 3-year longitudinal study in a specialized intervention program (PAFIP)

Relapses may represent a critical hazard in schizophrenia spectrum disorders as they are associated with an increased risk of a clinical and functional deterioration. Preventing relapse after recovering from a first psychotic episode has become a major challenge due to its critical impact on lifelon...

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Published in:European archives of psychiatry and clinical neuroscience 2017-06, Vol.267 (4), p.315-323
Main Authors: Pelayo-Terán, José María, Gajardo Galán, Virginia Gajardo, de la Ortiz-García de la Foz, Víctor, Martínez-García, Obdulia, Tabarés-Seisdedos, Rafael, Crespo-Facorro, Benedicto, Ayesa-Arriola, Rosa
Format: Article
Language:English
Subjects:
Adolescent
Adult
Antipsychotic Agents - therapeutic use
Female
Humans
Logistic Models
Longitudinal Studies
Male
Medicine
Medicine & Public Health
Mental disorders
Middle Aged
Neurosciences
Original Paper
Patient Compliance - psychology
Patient Compliance - statistics & numerical data
Predictive Value of Tests
Psychiatric Status Rating Scales
Psychiatry
Psychosis
Psychotic Disorders - diagnosis
Psychotic Disorders - drug therapy
Psychotic Disorders - epidemiology
Recurrence
Retrospective Studies
Risk Factors
Schizophrenia
Young Adult
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Summary:Relapses may represent a critical hazard in schizophrenia spectrum disorders as they are associated with an increased risk of a clinical and functional deterioration. Preventing relapse after recovering from a first psychotic episode has become a major challenge due to its critical impact on lifelong functionality. This study explored the rate of first and second relapses and the predictors associated with these relapses in a large cohort of non-affective psychosis patients during a period of 3 years after the first break of the illness. From February 2001 to May 2014, sociodemographic and clinical data from an epidemiological cohort of 341 non-affective first-episode psychosis patients at risk of relapse were analysed at a specialized early intervention service. Logistic regression, Cox regression, and Kaplan–Meier survival analyses were performed to compare non-relapsed and relapsed patients. One hundred and sixty-six (48.7%) individuals relapsed at least once. Median time to relapse was 17.0 months in non-adherent patients and 40.0 months in adherent patients (log-rank χ 2 : 51.36; p  
ISSN:0940-1334
1433-8491
DOI:10.1007/s00406-016-0740-3