Human leucocyte antigen (HLA) class I and II typing in Belgian multiple sclerosis patients

This is one of the first studies to compare the frequencies of different human leucocyte antigen (HLA) class I and II alleles and haplotype HLA-DRB1*15-DQB1*06 in a cohort of 119 patients with multiple sclerosis (MS) and a cohort of 124 healthy controls in Belgium. An association with MS was found f...

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Bibliographic Details
Published in:Acta neurologica Belgica 2017-03, Vol.117 (1), p.61-65
Main Authors: Lysandropoulos, Andreas P., Racapé, Judith, Holovska, Vanda, Toungouz, Michel
Format: Article
Language:English
Subjects:
Adult
Belgium
Biomedical and Life Sciences
Biomedicine
Female
Gene Frequency
Genetic Predisposition to Disease - genetics
Haplotypes
Histocompatibility Antigens Class I - genetics
Histocompatibility Antigens Class II - genetics
Humans
Male
Medicine/Public Health
Middle Aged
Multiple Sclerosis - genetics
Neurology
Neuroradiology
Neurosciences
Original Article
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Summary:This is one of the first studies to compare the frequencies of different human leucocyte antigen (HLA) class I and II alleles and haplotype HLA-DRB1*15-DQB1*06 in a cohort of 119 patients with multiple sclerosis (MS) and a cohort of 124 healthy controls in Belgium. An association with MS was found for the HLA-DRB1*15 (odds ratio [OR] 2.60 [95% confidence interval (CI) 1.51–4.50]) and HLA-DQB1*06 (OR 1.97 [95% CI 1.18–3.29]) alleles, and for haplotype DRB1*15-DQB1*06 (OR 2.63 [95% CI 1.52–4.56]). The HLA-B*07 allele also tended to be more frequent in MS patients (OR 1.46 [95% CI 0.80–2.65]) and more frequent among MS patients with than in those without the HLA-DRB1*15 allele (26/54 [48.1%] versus 6/65 [9.2%]; p value
ISSN:0300-9009
2240-2993
DOI:10.1007/s13760-016-0716-0