MRSA infections among patients in the emergency department: a European multicentre study

• Published in: Journal of antimicrobial chemotherapy 2017-02, Vol.72 (2), p.372-375
• Main Authors: Bouchiat, C, Curtis, S, Spiliopoulou, I, Bes, M, Cocuzza, C, Codita, I, Dupieux, C, Giormezis, N, Kearns, A, Laurent, F, Molinos, S, Musumeci, R, Prat, C, Saadatian-Elahi, M, Tacconelli, E, Tristan, A, Schulte, B, Vandenesch, F
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Bacterial Toxins - genetics; Child; Child, Preschool; Community-Acquired Infections - epidemiology; Community-Acquired Infections - microbiology; Emergency Service, Hospital; Europe - epidemiology; Exotoxins - genetics; Female; Genotype; Humans; Infant; Leukocidins - genetics; Male; Methicillin-Resistant Staphylococcus aureus - classification; Methicillin-Resistant Staphylococcus aureus - drug effects; Methicillin-Resistant Staphylococcus aureus - genetics; Methicillin-Resistant Staphylococcus aureus - isolation & purification; Microarray Analysis; Microbial Sensitivity Tests; Middle Aged; Molecular Epidemiology; Multilocus Sequence Typing; Oligonucleotide Array Sequence Analysis; Prevalence; Prospective Studies; Soft Tissue Infections - epidemiology; Soft Tissue Infections - microbiology; Staphylococcal Infections - epidemiology; Staphylococcal Infections - microbiology; Staphylococcal Protein A - genetics; Tertiary Care Centers; Young Adult
• ISSN: 0305-7453; 1460-2091
• DOI: 10.1093/jac/dkw431

MRSA is a therapeutic concern worldwide, and a major agent of community-acquired skin and soft tissue infections (CA-SSTIs). While the US epidemiology of MRSA in CA-SSTIs is well described and reports the high prevalence of the USA300 clone, data on the European situation are lacking. To determine the prevalence and clonal characteristics of MRSA in CA-SSTIs in seven European emergency departments. From April to June 2015, patients presenting to the tertiary hospital emergency department with a Staphylococcus aureus CA-SSTI were prospectively enrolled. S. aureus isolates were characterized by antimicrobial susceptibility testing, detection of Panton-Valentine leucocidin encoding genes and spa-typing, MLST and/or DNA microarray. Two-hundred and five cases of S. aureus-associated CA-SSTIs were included, comprising folliculitis, furuncles, abscesses, paronychia, impetigo, carbuncles and cellulitis. Of the 205 cases, we report an MRSA prevalence rate of 15.1%, with a north (0%) to south (29%) increasing gradient. Fifty-one isolates were Panton-Valentine leucocidin-positive (24.9%), whether MSSA or MRSA, with a heterogeneous distribution between countries. Clonal distribution of MSSA and MRSA showed high diversity, with no predominant circulating clone and no archetypical USA300 CA-MRSA clone. This original prospective multicentre study highlights stark differences in European MRSA epidemiology compared with the USA, and that the USA300 CA-MRSA clone is not predominant among community-infected patients in Europe.