Relevance of carnosic acid to the treatment of several health disorders: Molecular targets and mechanisms

Abstract Carnosic acid is a phenolic diterperne compound found in abundance in sage and rosemary, which are both widely used in traditional medicine. Research over the past decade indicates that carnosic acid has multiple bioactive properties including antioxidant, anti-inflammatory and anticancer a...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2016-12, Vol.84, p.569-582
Main Authors: Bahri, Sana, Jameleddine, Saloua, Shlyonsky, Vadim
Format: Article
Language:English
Subjects:
Animals
Anti-inflammatory
Anti-Obesity Agents - adverse effects
Anti-Obesity Agents - pharmacokinetics
Anti-Obesity Agents - therapeutic use
Antineoplastic Agents, Phytogenic - adverse effects
Antineoplastic Agents, Phytogenic - pharmacokinetics
Antineoplastic Agents, Phytogenic - therapeutic use
Antioxidant
Antitumor
Biological Availability
Carnosic acid
Dermatologic Agents - adverse effects
Dermatologic Agents - pharmacokinetics
Dermatologic Agents - therapeutic use
Disease Models, Animal
Diterpenes, Abietane - adverse effects
Diterpenes, Abietane - pharmacokinetics
Diterpenes, Abietane - therapeutic use
Gastrointestinal Agents - adverse effects
Gastrointestinal Agents - pharmacokinetics
Gastrointestinal Agents - therapeutic use
Humans
Internal Medicine
Medical Education
Neuroprotective Agents - adverse effects
Neuroprotective Agents - pharmacokinetics
Neuroprotective Agents - therapeutic use
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Summary:Abstract Carnosic acid is a phenolic diterperne compound found in abundance in sage and rosemary, which are both widely used in traditional medicine. Research over the past decade indicates that carnosic acid has multiple bioactive properties including antioxidant, anti-inflammatory and anticancer activities among others. This review summarizes the current in vitro and in vivo data about the efficacy of carnosic acid in the prevention or treatment of various experimental health disorders. The analysis of the literature allows an insight into the participation of numerous signaling pathways modulated by carnosic acid, into its synergistic potential and, thus, into the divergence in cellular mechanisms of action of this molecule.
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2016.09.067