Risky decision-making in adolescent girls: The role of pubertal hormones and reward circuitry

Highlights • We administered a probabilistic decision task to 11-to-13-year-old girls in the MRI scanner. • Girls with higher saliva-based testosterone levels made more risky decisions. • The relation between testosterone and risk taking was mediated by increased activation in the medial orbitofront...

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Bibliographic Details
Published in:Psychoneuroendocrinology 2016-12, Vol.74, p.77-91
Main Authors: Op de Macks, Zdeňa A, Bunge, Silvia A, Bell, Orly N, Wilbrecht, Linda, Kriegsfeld, Lance J, Kayser, Andrew S, Dahl, Ronald E
Format: Article
Language:English
Subjects:
Adolescent
Adolescent Behavior - physiology
Child
Child Behavior - physiology
Decision Making - physiology
Endocrinology & Metabolism
Estradiol
Estradiol - metabolism
Estradiol - physiology
Female
fMRI
Humans
Magnetic Resonance Imaging
Nucleus accumbens
Nucleus Accumbens - diagnostic imaging
Nucleus Accumbens - physiology
Orbitofrontal cortex
Prefrontal Cortex - diagnostic imaging
Prefrontal Cortex - physiology
Psychiatry
Puberty
Puberty - metabolism
Puberty - physiology
Reward
Risk-Taking
Testosterone
Testosterone - metabolism
Testosterone - physiology
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Summary:Highlights • We administered a probabilistic decision task to 11-to-13-year-old girls in the MRI scanner. • Girls with higher saliva-based testosterone levels made more risky decisions. • The relation between testosterone and risk taking was mediated by increased activation in the medial orbitofrontal cortex. • Estradiol level and risk taking were indirectly related through nucleus accumbens activation.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2016.08.013