Relationships between serum BDNF and the antidepressant effect of acute exercise in depressed women

Highlights • Acute BDNF change is not related to acute improvement in depressed mood in MDD. • Acute BDNF change is also not exercise intensity dependent. • Pre-exercise depressive symptoms predict BDNF change post-exercise. • Antidepressant usage limited post-exercise BDNF suggesting blunted sensit...

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Bibliographic Details
Published in:Psychoneuroendocrinology 2016-12, Vol.74, p.286-294
Main Authors: Meyer, Jacob D, Koltyn, Kelli F, Stegner, Aaron J, Kim, Jee-Seon, Cook, Dane B
Format: Article
Language:English
Subjects:
Adult
Antidepressant response
Antidepressive Agents - therapeutic use
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - blood
Depression
Depressive Disorder, Major - blood
Depressive Disorder, Major - therapy
Endocrinology & Metabolism
Exercise
Exercise intensity
Exercise Therapy - methods
Female
Humans
Middle Aged
Mood
Psychiatry
Treatment Outcome
Young Adult
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Summary:Highlights • Acute BDNF change is not related to acute improvement in depressed mood in MDD. • Acute BDNF change is also not exercise intensity dependent. • Pre-exercise depressive symptoms predict BDNF change post-exercise. • Antidepressant usage limited post-exercise BDNF suggesting blunted sensitivity. • The exercise-BDNF-symptom relationships are worthy of continued research in MDD.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2016.09.022