Reevaluation of anti-obesity action of mazindol and elucidation of its effect on the reward system

• Published in: Neuroscience letters 2016-10, Vol.633, p.141-145
• Main Authors: Aotani, Daisuke, Son, Cheol, Shimizu, Yoshiyuki, Nomura, Hidenari, Hikida, Takatoshi, Kusakabe, Toru, Tanaka, Tomohiro, Miyazawa, Takashi, Hosoda, Kiminori, Nakao, Kazuwa
• Format: Article
• Language: English
• Subjects: Animals; Anti-Obesity Agents - pharmacology; Conditioned place preference; Conditioning (Psychology) - drug effects; Dietary Fats - administration & dosage; Drug Tolerance; Food Preferences - drug effects; High fat diet; Infusions, Subcutaneous; Male; Mazindol; Mazindol - pharmacology; Mice, Inbred C57BL; Motor Activity - drug effects; Obesity; Reward; Reward system
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/j.neulet.2016.09.014

•Mazindol reduces body weight gain and hyperphagia induced by high-fat diet.•Mazindol decreases preference for lipid emulsion.•Mazindol decreases conditioned place preference for high-fat diet.•Mazindol at the dose required for these effects does not elicit abuse potential. In this study, we evaluated the preventive effect of mazindol on the development of obesity and sought to elucidate the drug’s effects on the reward system. In mice, body weight gain and hyperphagia induced by high-fat diet (HFD) were decreased by 38.6% and 13.9%, respectively, by subcutaneous infusion of mazindol (1.5mg/kg/day) for 28days. A single intraperitoneal administration of mazindol (1.5mg/kg) significantly reduced lipid preference, as assessed using the two-bottle preference paradigm (vehicle, 89.98±1.66%; mazindol, 75.65±5.47%; p