Reversible Facial Hyperpigmentation Associated With Vitamin B12 Deficiency

Vitamin B12 (cobalamin) deficiency is common in developing countries. Its dermatologic manifestations include hair and nail changes and glossitis. Cases of generalized hyperpigmentation associated with vitamin B12 deficiency have rarely been reported. Localized hyperpigmentation is less frequently d...

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Bibliographic Details
Published in:Nutrition in clinical practice 2017-04, Vol.32 (2), p.275-276
Main Authors: Tayem, Leeda, Litaiem, Noureddine, Jones, Mariem, Zeglaoui, Faten
Format: Article
Language:English
Subjects:
Anemia, Pernicious - complications
Anemia, Pernicious - diagnosis
Anemia, Pernicious - drug therapy
cobalamin
Diagnosis, Differential
Female
Humans
hyperpigmentation
Hyperpigmentation - diagnosis
Hyperpigmentation - drug therapy
Hyperpigmentation - etiology
Injections, Intramuscular
Magnetic Resonance Imaging
Middle Aged
Nursing
pernicious anemia
Vitamin B 12 - administration & dosage
vitamin B12
vitamin B12 deficiency
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Description
Summary:Vitamin B12 (cobalamin) deficiency is common in developing countries. Its dermatologic manifestations include hair and nail changes and glossitis. Cases of generalized hyperpigmentation associated with vitamin B12 deficiency have rarely been reported. Localized hyperpigmentation is less frequently described, affecting palms, soles, and flexural areas. We report a rare case of reversible melasma-like cutaneous hyperpigmentation associated with pernicious anemia and discuss the possible mechanisms of this association.
ISSN:0884-5336
1941-2452
DOI:10.1177/0884533616670380