The Emulsified PFC Oxycyte® Improved Oxygen Content and Lung Injury Score in a Swine Model of Oleic Acid Lung Injury (OALI)

Purpose Perfluorocarbons (PFCs) can transport 50 times more oxygen than human plasma. Their properties may be advantageous in preservation of tissue viability in oxygen-deprived states, such as in acute lung injury. We hypothesized that an intravenous dose of the PFC emulsion Oxycyte ® would improve...

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Bibliographic Details
Published in:Lung 2016-12, Vol.194 (6), p.945-957
Main Authors: Haque, Ashraful, Scultetus, Anke H., Arnaud, Francoise, Dickson, Leonora J., Chun, Steve, McNamee, George, Auker, Charles R., McCarron, Richard M., Mahon, Richard T.
Format: Article
Language:English
Subjects:
Acid-Base Equilibrium
Acute Lung Injury - chemically induced
Acute Lung Injury - drug therapy
Acute Lung Injury - pathology
Administration, Intravenous
Animals
Arterial Pressure - drug effects
Blood Gas Analysis
Disease Models, Animal
Female
Fluorocarbons - administration & dosage
Fluorocarbons - adverse effects
Lactic Acid - blood
Male
Medicine
Medicine & Public Health
Oleic Acid
Oxygen - blood
Pneumology/Respiratory System
Pulmonary Wedge Pressure - drug effects
Respiratory Distress Syndrome, Adult - drug therapy
Severity of Illness Index
Survival Rate
Swine
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Summary:Purpose Perfluorocarbons (PFCs) can transport 50 times more oxygen than human plasma. Their properties may be advantageous in preservation of tissue viability in oxygen-deprived states, such as in acute lung injury. We hypothesized that an intravenous dose of the PFC emulsion Oxycyte ® would improve tissue oxygenation and thereby mitigate the effects of acute lung injury. Methods Intravenous oleic acid (OA) was used to induce lung injury in anesthetized and instrumented Yorkshire swine assigned to three experimental groups: (1) PFC post-OA received Oxycyte ® (5 ml/kg) 45 min after oleic acid-induced lung injury (OALI); (2) PFC pre-OA received Oxycyte ® 45 min before OALI; and (3) Controls which received equivalent dose of normal saline. Animals were observed for 3 h after OALI began, and then euthanized. Results The median survival times for PFC post-OA, PFC pre-OA, and control were 240, 87.5, and 240 min, respectively ( p  = 0.001). Mean arterial pressure and mean pulmonary arterial pressure were both higher in the PFC post-OA ( p  
ISSN:0341-2040
1432-1750
DOI:10.1007/s00408-016-9941-9