Expression and clinical significance of the obesity-related gene TNFAIP9 in obese children

To investigate the expression of tumor necrosis factor-alpha inducible protein 9 (TNFAIP9) gene in obese children and its clinical significance, 36 simple obese children and 17 non-obese children were recruited as research subjects. The adipose tissue was obtained by abdominal operation. The express...

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Bibliographic Details
Published in:Genetics and molecular research 2016-08, Vol.15 (3)
Main Authors: Gui, L Y, Hu, Y L, Hou, Z L, Wang, P
Format: Article
Language:English
Subjects:
Adipose Tissue - chemistry
Adipose Tissue - metabolism
Adipose Tissue - pathology
Adolescent
Blood Glucose - metabolism
Body Mass Index
Child
Female
Humans
Insulin - blood
Insulin Resistance
Lipids - blood
Male
Membrane Proteins - blood
Membrane Proteins - genetics
Obesity - blood
Obesity - genetics
Oxidoreductases - blood
Oxidoreductases - genetics
Triglycerides - blood
Waist Circumference
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Summary:To investigate the expression of tumor necrosis factor-alpha inducible protein 9 (TNFAIP9) gene in obese children and its clinical significance, 36 simple obese children and 17 non-obese children were recruited as research subjects. The adipose tissue was obtained by abdominal operation. The expression of TNFAIP9 was detected using real-time fluorescence quantitative polymerase chain reaction and western blot. The relationship between the expression of TNFAIP9 and blood lipid, blood glucose, and obesity indexes was analyzed. The levels of TNFAIP9 mRNA and protein in obese children were significantly lower than those in the control group (P < 0.05). The waist circumference (wc), body mass, body mass index (BMI), fat, total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), insulin resistance index (HOMA-IR), and endothelin (ET) in obese children were significantly higher than those in the control group. The level of high-density lipoprotein cholesterol (HDL-C) was significantly lower than that in the control group (P < 0.05). The level of TNFAIP9 protein was negatively correlated with the wc, body mass, BMI, fat, TC, TG, LDL-C, HOMA-IR, and ET (P < 0.05) and was positively correlated with the level of HDL-C (P < 0.05). In conclusion, the expression of TNFAIP9 significantly decreased in the adipose tissue of obese children, and its levels are closely related to blood lipid level, insulin resistance, and obesity.
ISSN:1676-5680
1676-5680
DOI:10.4238/gmr.15037995