High serum levels of sclerostin and Dickkopf-1 are associated with acute ischaemic stroke

Abstract Background and aims Sclerostin and Dickkopf-1 (Dkk-1) are potent antagonists of Wnt signalling and might therefore play important roles in cardiovascular disease. We investigated whether serum sclerostin and Dkk-1 levels are associated with acute ischaemic stroke and specific stroke subtype...

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Published in:Atherosclerosis 2016-10, Vol.253, p.22-28
Main Authors: He, Xin-Wei, Wang, En, Bao, Yu-Yan, Wang, Feng, Zhu, Ming, Hu, Xiao-Fei, Jin, Xiao-Ping
Format: Article
Language:English
Subjects:
Acute Disease
Aged
Area Under Curve
Atherosclerosis - physiopathology
Blood Pressure
Bone Morphogenetic Proteins - blood
Brain Ischemia - blood
Cardiovascular
Case-Control Studies
Cohort Studies
Dickkopf-1
Female
Genetic Markers
Humans
Intercellular Signaling Peptides and Proteins - blood
Ischaemic stroke
Male
Middle Aged
Regression Analysis
Reproducibility of Results
Sclerostin
Signal Transduction
Stroke - blood
Time Factors
Wnt pathways
Wnt Proteins - metabolism
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Summary:Abstract Background and aims Sclerostin and Dickkopf-1 (Dkk-1) are potent antagonists of Wnt signalling and might therefore play important roles in cardiovascular disease. We investigated whether serum sclerostin and Dkk-1 levels are associated with acute ischaemic stroke and specific stroke subtypes. Methods Serum levels of sclerostin and Dkk-1 were measured by ELISA on day 1 and on day 6 after stroke in 62 patients with large artery atherosclerotic (LAA) stroke, on day 1 after stroke in 62 age- and gender-matched patients with small-artery occlusion (SAO) stroke and on admission in 62 healthy controls. Stroke severity was determined based on the National Institutes of Health Stroke Scale (NIHSS) and by measuring stroke volume on diffusion-weighted imaging. Outcome was measured by the modified Rankin Scale (mRS) on day 90. Results Compared with controls, serum sclerostin and Dkk-1 levels were significantly higher in both patients with LAA stroke and with SAO stroke, and no difference was detected between the stroke subtypes. Sclerostin and Dkk-1 levels remained stable between the first and sixth day after stroke in the patients with LAA stroke. Receiver operating characteristic curve analysis was used to evaluate sclerostin and Dkk-1 as markers of a high risk of stroke and produced area under curve values of 0.773 and 0.776. Adjusted logistic regression showed that serum sclerostin and Dkk-1 levels remained as independent markers of stroke. No correlations were found between sclerostin or Dkk-1 levels and stroke severity or stroke outcome. Conclusions High serum levels of sclerostin and Dkk-1 are associated with acute ischaemic stroke.
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2016.08.003