The hypoxia-inducible factor (HIF) couples immunity with metabolism

Highlights • The hypoxia-inducible factor (HIF) is regulated by multiple metabolic and immune signals. • HIF regulates the expression of genes which contribute to both metabolism and immunity. • HIF is a key link between metabolic function and host defence. • HIF may be an important new target in in...

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Bibliographic Details
Published in:Seminars in immunology 2016-10, Vol.28 (5), p.469-477
Main Authors: Halligan, Doug N, Murphy, Stephen J.E, Taylor, Cormac T
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Energy Metabolism - drug effects
Gene Expression Regulation - drug effects
Humans
Hypoxia
Hypoxia - genetics
Hypoxia - immunology
Hypoxia - metabolism
Hypoxia-Inducible Factor 1 - metabolism
Immunity
Immunometabolism
Immunometabolite
Immunomodulation
Inflammation - drug therapy
Inflammation - etiology
Inflammation - metabolism
Mitochondria
Mixed Function Oxygenases - antagonists & inhibitors
Molecular Targeted Therapy
Signal Transduction - drug effects
Therapeutics
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Summary:Highlights • The hypoxia-inducible factor (HIF) is regulated by multiple metabolic and immune signals. • HIF regulates the expression of genes which contribute to both metabolism and immunity. • HIF is a key link between metabolic function and host defence. • HIF may be an important new target in inflammatory and infectious disease.
ISSN:1044-5323
1096-3618
DOI:10.1016/j.smim.2016.09.004