Human Dopamine Receptor-Conjugated Multidimensional Conducting Polymer Nanofiber Membrane for Dopamine Detection

In the brain and central nervous system, dopamine plays a crucial role as a neurotransmitter or a local chemical messenger for interneuronal communication. Dopamine is associated with renal, hormonal, and cardiovascular systems. Additionally, dopamine dysfunction is known to cause serious illnesses,...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2016-10, Vol.8 (42), p.28897-28903
Main Authors: Park, Seon Joo, Lee, Seung Hwan, Yang, Heehong, Park, Chul Soon, Lee, Chang-Soo, Kwon, Oh Seok, Park, Tai Hyun, Jang, Jyongsik
Format: Article
Language:English
Subjects:
Biosensing Techniques
Dopamine
Humans
Nanofibers
Polymers
Receptors, Dopamine
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Summary:In the brain and central nervous system, dopamine plays a crucial role as a neurotransmitter or a local chemical messenger for interneuronal communication. Dopamine is associated with renal, hormonal, and cardiovascular systems. Additionally, dopamine dysfunction is known to cause serious illnesses, such as Parkinson’s disease and Alzheimer’s disease. Therefore, dopamine detection is essential for medical diagnosis and disease prevention and requires a novel strategy with high sensitivity and selectivity and a rapid response. Herein, we present a novel human dopamine receptor (hDRD1)-conjugated multidimensional conducting polymer nanofiber (NF) membrane for the selective and sensitive detection of dopamine. The membrane, which consists of multidimensional carboxylated poly­(3,4-ethylene­dioxythiophene) (MCPEDOT) NFs with nanorods, is used as a transistor in a liquid-ion gated field-effect transistor (FET)-based biosensor. Interestingly, hDRD1 is first expressed in Escherichia coli before it is immobilized onto the MCPEDOT NF. The hDRD1–MCPEDOT NF-based FET exhibits a rapid real-time response (
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.6b10437