Foeniculum vulgare extract and its constituent, trans -anethole, inhibit UV-induced melanogenesis via ORAI1 channel inhibition

Highlights • ORAI1 is involved in UV-induced melanogenesis. • F. vulgare extract, which prevent UV-induced melanogenesis, inhibited ORAI1 and tyrosinase activity. • trans -Anethole (TA) was isolated from F. vulgare extract. • TA inhibited UV-induced melanogenesis via ORAI1 inhibition without affecti...

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Bibliographic Details
Published in:Journal of dermatological science 2016-12, Vol.84 (3), p.305-313
Main Authors: Nam, Joo Hyun, PhD, Lee, Dong-Ung, PhD
Format: Article
Language:English
Subjects:
Animals
Anisoles - pharmacology
Calcium - metabolism
Cell Survival
Dermatology
Foeniculum - chemistry
Foeniculum vulgare
Fruit - chemistry
HEK293 Cells
Humans
Inhibitory Concentration 50
Melanocytes - cytology
Melanocytes - drug effects
Melanogenesis
Melanoma, Experimental
Mice
Monophenol Monooxygenase - metabolism
Neoplasm Proteins - metabolism
ORAI1 channel
ORAI1 Protein - antagonists & inhibitors
ORAI1 Protein - metabolism
Patch-Clamp Techniques
Plant Extracts - pharmacology
Powders
Stromal Interaction Molecule 1 - metabolism
trans-Anethole
Tyrosinase
Ultraviolet
Ultraviolet Rays
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Summary:Highlights • ORAI1 is involved in UV-induced melanogenesis. • F. vulgare extract, which prevent UV-induced melanogenesis, inhibited ORAI1 and tyrosinase activity. • trans -Anethole (TA) was isolated from F. vulgare extract. • TA inhibited UV-induced melanogenesis via ORAI1 inhibition without affecting tyrosinase activity. • TA might provide a novel option for treating UV-induced melanogenesis.
ISSN:0923-1811
1873-569X
DOI:10.1016/j.jdermsci.2016.09.017