A 14-year-old boy with extranodal natural killer cell lymphoma of the nose, nasopharynx, larynx, and trachea in remission 6years after primary diagnosis. A longitudinal case report

Nasal type extranodal natural killer/T-cell lymphoma (ENKTL) is a rare lymphoma in the USA and Europe but endemic in East Asia and in areas of South and Central America. Clinically natural killer cell lymphomas are divided into three categories; nasal, non-nasal and aggressive lymphoma/leukemia subt...

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Bibliographic Details
Published in:American journal of otolaryngology 2016-11, Vol.37 (6), p.563-566
Main Authors: Gungor, Anil, Pennington, Lindsey, Sankararaman, Senthil, Zaid-Kaylani, Samer, Jeroudi, Majed Aldin
Format: Article
Language:English
Subjects:
Adolescent
Biopsy
Bone marrow
Caregivers
Chemotherapy
Endoscopy
Humans
Larynx
Leukemia
Lymphoma
Lymphoma, Extranodal NK-T-Cell - diagnosis
Lymphoma, Extranodal NK-T-Cell - therapy
Male
Nose
Ostomy
Otorhinolaryngologic Neoplasms - diagnosis
Otorhinolaryngologic Neoplasms - therapy
Pediatrics
Radiation therapy
Stem cells
Tracheal Neoplasms - diagnosis
Tracheal Neoplasms - therapy
Transplants & implants
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Summary:Nasal type extranodal natural killer/T-cell lymphoma (ENKTL) is a rare lymphoma in the USA and Europe but endemic in East Asia and in areas of South and Central America. Clinically natural killer cell lymphomas are divided into three categories; nasal, non-nasal and aggressive lymphoma/leukemia subtypes. ENKTL, nasal type occurs in the nose and can extend to the upper aero-digestive tract as reported in this longitudinal case study. This is a longitudinal report of progress of a 14-year-old boy with ENKTL originating in the nasal cavity with subsequent extension and recurrence in the contralateral nose, nasopharynx, larynx and trachea presenting with varying degrees of respiratory problems and eventually, respiratory distress. Caregiver refusal of stem cell transplantation prompted an alternative diagnostic and therapeutic approach. Clinical course with recurrences, extensions and remissions over 6years with tailored endoscopic surgical treatment and radiochemotherapy is documented to present a guide in the multidisciplinary management of this rare disease.
ISSN:0196-0709
1532-818X
DOI:10.1016/j.amjoto.2016.08.004