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Factors associated with pulmonary hypertension and long-term survival in bronchiectasis subjects
Abstract Background The development of pulmonary hypertension (PH) and its effect on long-term survival in bronchiectasis subjects has not been explored. The present study aims to analyze the factors associated with PH and its effect on long-term survival in bronchiectasis subjects. Methods We prosp...
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| Published in: | Respiratory medicine 2016-10, Vol.119, p.109-114 |
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| creator | Öcal, Serpil Portakal, Oytun Öcal, Arslan Demir, Ahmet Uğur Topeli, Arzu Çöplü, Lütfi |
| description | Abstract Background The development of pulmonary hypertension (PH) and its effect on long-term survival in bronchiectasis subjects has not been explored. The present study aims to analyze the factors associated with PH and its effect on long-term survival in bronchiectasis subjects. Methods We prospectively evaluated 23 bronchiectasis subjects without PH and 16 with PH, as well as 20 healthy volunteers. Results Bronchiectasis subjects with PH were more hypoxemic and had a greater number of involved lobes in high resolution computed tomography (HRCT) than did the bronchiectasis subjects without PH (P |
| doi_str_mv | 10.1016/j.rmed.2016.08.027 |
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The present study aims to analyze the factors associated with PH and its effect on long-term survival in bronchiectasis subjects. Methods We prospectively evaluated 23 bronchiectasis subjects without PH and 16 with PH, as well as 20 healthy volunteers. Results Bronchiectasis subjects with PH were more hypoxemic and had a greater number of involved lobes in high resolution computed tomography (HRCT) than did the bronchiectasis subjects without PH (P < 0.001 and P < 0.001, respectively). At three years, the survival rate was 95.7% for bronchiectasis subjects without PH and 56.3% for bronchiectasis with PH, and at 5 years, these rates were 95.7% and 62.5%, respectively (P = 0.002). Multivariate Cox regression analysis revealed that only the Medical Research Council (MRC) dyspnea score was independently related to poor survival in all bronchiectasis subjects (hazard ratio: 6.98; 95% CI: 2.41–20.23; P < 0.00001). Conclusions Subjects with PH are more hypoxemic and have a greater number of involvements in the lobes of the lungs. Bronchiectasis subjects with PH have worse survival than do bronchiectasis subjects without PH. MRC dyspnea score is an independent predictor of long-term survival.</description><identifier>ISSN: 0954-6111</identifier><identifier>EISSN: 1532-3064</identifier><identifier>DOI: 10.1016/j.rmed.2016.08.027</identifier><identifier>PMID: 27692130</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Body mass index ; Bronchiectasis ; Bronchiectasis - complications ; Bronchiectasis - diagnostic imaging ; Bronchiectasis - epidemiology ; Bronchiectasis - metabolism ; Cardiovascular disease ; Chronic obstructive pulmonary disease ; Clinical Trials as Topic ; Coronary vessels ; Dyspnea ; Dyspnea - diagnosis ; Dyspnea - etiology ; Echocardiography, Doppler - methods ; Endothelin-1 ; Endothelin-1 - blood ; Endothelin-1 - urine ; Female ; Humans ; Hypertension, Pulmonary - complications ; Hypoxemia ; Hypoxia - complications ; Male ; Medical imaging ; Medical prognosis ; Medical research ; Middle Aged ; Mortality ; Oxygen - blood ; Oxygen - metabolism ; Patient Outcome Assessment ; Plasma ; Prospective Studies ; Pulmonary arteries ; Pulmonary hypertension ; Pulmonary/Respiratory ; Risk Factors ; Survival ; Survival Rate ; Tomography ; Tomography, X-Ray Computed - methods ; Turkey - epidemiology ; Ultrasonic imaging ; Veins & arteries ; Velocity ; Ventricular Dysfunction, Right - complications ; Ventricular Dysfunction, Right - diagnostic imaging</subject><ispartof>Respiratory medicine, 2016-10, Vol.119, p.109-114</ispartof><rights>Elsevier Ltd</rights><rights>2016 Elsevier Ltd</rights><rights>Copyright © 2016 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Oct 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-f167eaed4e8382f9b795354e5a0dc4cf3628a7728658756cd18dc87fe01e8d6c3</citedby><cites>FETCH-LOGICAL-c483t-f167eaed4e8382f9b795354e5a0dc4cf3628a7728658756cd18dc87fe01e8d6c3</cites><orcidid>0000-0002-0078-0858</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27692130$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Öcal, Serpil</creatorcontrib><creatorcontrib>Portakal, Oytun</creatorcontrib><creatorcontrib>Öcal, Arslan</creatorcontrib><creatorcontrib>Demir, Ahmet Uğur</creatorcontrib><creatorcontrib>Topeli, Arzu</creatorcontrib><creatorcontrib>Çöplü, Lütfi</creatorcontrib><title>Factors associated with pulmonary hypertension and long-term survival in bronchiectasis subjects</title><title>Respiratory medicine</title><addtitle>Respir Med</addtitle><description>Abstract Background The development of pulmonary hypertension (PH) and its effect on long-term survival in bronchiectasis subjects has not been explored. The present study aims to analyze the factors associated with PH and its effect on long-term survival in bronchiectasis subjects. Methods We prospectively evaluated 23 bronchiectasis subjects without PH and 16 with PH, as well as 20 healthy volunteers. Results Bronchiectasis subjects with PH were more hypoxemic and had a greater number of involved lobes in high resolution computed tomography (HRCT) than did the bronchiectasis subjects without PH (P < 0.001 and P < 0.001, respectively). At three years, the survival rate was 95.7% for bronchiectasis subjects without PH and 56.3% for bronchiectasis with PH, and at 5 years, these rates were 95.7% and 62.5%, respectively (P = 0.002). Multivariate Cox regression analysis revealed that only the Medical Research Council (MRC) dyspnea score was independently related to poor survival in all bronchiectasis subjects (hazard ratio: 6.98; 95% CI: 2.41–20.23; P < 0.00001). Conclusions Subjects with PH are more hypoxemic and have a greater number of involvements in the lobes of the lungs. Bronchiectasis subjects with PH have worse survival than do bronchiectasis subjects without PH. MRC dyspnea score is an independent predictor of long-term survival.</description><subject>Adult</subject><subject>Body mass index</subject><subject>Bronchiectasis</subject><subject>Bronchiectasis - complications</subject><subject>Bronchiectasis - diagnostic imaging</subject><subject>Bronchiectasis - epidemiology</subject><subject>Bronchiectasis - metabolism</subject><subject>Cardiovascular disease</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Clinical Trials as Topic</subject><subject>Coronary vessels</subject><subject>Dyspnea</subject><subject>Dyspnea - diagnosis</subject><subject>Dyspnea - etiology</subject><subject>Echocardiography, Doppler - methods</subject><subject>Endothelin-1</subject><subject>Endothelin-1 - blood</subject><subject>Endothelin-1 - urine</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension, Pulmonary - complications</subject><subject>Hypoxemia</subject><subject>Hypoxia - complications</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Oxygen - blood</subject><subject>Oxygen - metabolism</subject><subject>Patient Outcome Assessment</subject><subject>Plasma</subject><subject>Prospective Studies</subject><subject>Pulmonary arteries</subject><subject>Pulmonary hypertension</subject><subject>Pulmonary/Respiratory</subject><subject>Risk Factors</subject><subject>Survival</subject><subject>Survival Rate</subject><subject>Tomography</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Turkey - epidemiology</subject><subject>Ultrasonic imaging</subject><subject>Veins & arteries</subject><subject>Velocity</subject><subject>Ventricular Dysfunction, Right - complications</subject><subject>Ventricular Dysfunction, Right - diagnostic imaging</subject><issn>0954-6111</issn><issn>1532-3064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp9kk2LFDEQhoMo7jj6BzxIgxcv3earkzSIsCzurrDgQT3HTFLtpO1OxqR7ZP69aWYXYQ-eUlBPvaQeCqHXBDcEE_F-aNIErqGlbrBqMJVP0Ia0jNYMC_4UbXDX8loQQi7Qi5wHjHHHOX6OLqgUHSUMb9CPa2PnmHJlco7Wmxlc9cfP--qwjFMMJp2q_ekAaYaQfQyVCa4aY_hZz5CmKi_p6I9mrHyodikGu_dgZ5N9Lq3dUOr8Ej3rzZjh1f27Rd-vP327uq3vvtx8vrq8qy1XbK57IiQYcBwUU7TvdrJrWcuhNdhZbnsmqDJSUiVaJVthHVHOKtkDJqCcsGyL3p1zDyn-XiDPevLZwjiaAHHJmijWMsU7zgr69hE6xCWF8rtCUUWkwMXiFtEzZVPMOUGvD8lPRYgmWK_-9aBX_3r1r7HSxX8ZenMfvezW3sPIg_ACfDgDUFwcPSSdrYdgwflUdGkX_f_zPz4at6MP3prxF5wg_9tDZ6qx_rpewHoARDBMKcXsL2qKrIc</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Öcal, Serpil</creator><creator>Portakal, Oytun</creator><creator>Öcal, Arslan</creator><creator>Demir, Ahmet Uğur</creator><creator>Topeli, Arzu</creator><creator>Çöplü, Lütfi</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>ASE</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0078-0858</orcidid></search><sort><creationdate>20161001</creationdate><title>Factors associated with pulmonary hypertension and long-term survival in bronchiectasis subjects</title><author>Öcal, Serpil ; Portakal, Oytun ; Öcal, Arslan ; Demir, Ahmet Uğur ; Topeli, Arzu ; Çöplü, Lütfi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-f167eaed4e8382f9b795354e5a0dc4cf3628a7728658756cd18dc87fe01e8d6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Body mass index</topic><topic>Bronchiectasis</topic><topic>Bronchiectasis - complications</topic><topic>Bronchiectasis - diagnostic imaging</topic><topic>Bronchiectasis - epidemiology</topic><topic>Bronchiectasis - metabolism</topic><topic>Cardiovascular disease</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Clinical Trials as Topic</topic><topic>Coronary vessels</topic><topic>Dyspnea</topic><topic>Dyspnea - diagnosis</topic><topic>Dyspnea - etiology</topic><topic>Echocardiography, Doppler - methods</topic><topic>Endothelin-1</topic><topic>Endothelin-1 - blood</topic><topic>Endothelin-1 - urine</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension, Pulmonary - complications</topic><topic>Hypoxemia</topic><topic>Hypoxia - complications</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medical prognosis</topic><topic>Medical research</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Oxygen - blood</topic><topic>Oxygen - metabolism</topic><topic>Patient Outcome Assessment</topic><topic>Plasma</topic><topic>Prospective Studies</topic><topic>Pulmonary arteries</topic><topic>Pulmonary hypertension</topic><topic>Pulmonary/Respiratory</topic><topic>Risk Factors</topic><topic>Survival</topic><topic>Survival Rate</topic><topic>Tomography</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Turkey - epidemiology</topic><topic>Ultrasonic imaging</topic><topic>Veins & arteries</topic><topic>Velocity</topic><topic>Ventricular Dysfunction, Right - complications</topic><topic>Ventricular Dysfunction, Right - diagnostic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Öcal, Serpil</creatorcontrib><creatorcontrib>Portakal, Oytun</creatorcontrib><creatorcontrib>Öcal, Arslan</creatorcontrib><creatorcontrib>Demir, Ahmet Uğur</creatorcontrib><creatorcontrib>Topeli, Arzu</creatorcontrib><creatorcontrib>Çöplü, Lütfi</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Öcal, Serpil</au><au>Portakal, Oytun</au><au>Öcal, Arslan</au><au>Demir, Ahmet Uğur</au><au>Topeli, Arzu</au><au>Çöplü, Lütfi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors associated with pulmonary hypertension and long-term survival in bronchiectasis subjects</atitle><jtitle>Respiratory medicine</jtitle><addtitle>Respir Med</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>119</volume><spage>109</spage><epage>114</epage><pages>109-114</pages><issn>0954-6111</issn><eissn>1532-3064</eissn><abstract>Abstract Background The development of pulmonary hypertension (PH) and its effect on long-term survival in bronchiectasis subjects has not been explored. The present study aims to analyze the factors associated with PH and its effect on long-term survival in bronchiectasis subjects. Methods We prospectively evaluated 23 bronchiectasis subjects without PH and 16 with PH, as well as 20 healthy volunteers. Results Bronchiectasis subjects with PH were more hypoxemic and had a greater number of involved lobes in high resolution computed tomography (HRCT) than did the bronchiectasis subjects without PH (P < 0.001 and P < 0.001, respectively). At three years, the survival rate was 95.7% for bronchiectasis subjects without PH and 56.3% for bronchiectasis with PH, and at 5 years, these rates were 95.7% and 62.5%, respectively (P = 0.002). Multivariate Cox regression analysis revealed that only the Medical Research Council (MRC) dyspnea score was independently related to poor survival in all bronchiectasis subjects (hazard ratio: 6.98; 95% CI: 2.41–20.23; P < 0.00001). Conclusions Subjects with PH are more hypoxemic and have a greater number of involvements in the lobes of the lungs. Bronchiectasis subjects with PH have worse survival than do bronchiectasis subjects without PH. MRC dyspnea score is an independent predictor of long-term survival.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>27692130</pmid><doi>10.1016/j.rmed.2016.08.027</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-0078-0858</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Body mass index Bronchiectasis Bronchiectasis - complications Bronchiectasis - diagnostic imaging Bronchiectasis - epidemiology Bronchiectasis - metabolism Cardiovascular disease Chronic obstructive pulmonary disease Clinical Trials as Topic Coronary vessels Dyspnea Dyspnea - diagnosis Dyspnea - etiology Echocardiography, Doppler - methods Endothelin-1 Endothelin-1 - blood Endothelin-1 - urine Female Humans Hypertension, Pulmonary - complications Hypoxemia Hypoxia - complications Male Medical imaging Medical prognosis Medical research Middle Aged Mortality Oxygen - blood Oxygen - metabolism Patient Outcome Assessment Plasma Prospective Studies Pulmonary arteries Pulmonary hypertension Pulmonary/Respiratory Risk Factors Survival Survival Rate Tomography Tomography, X-Ray Computed - methods Turkey - epidemiology Ultrasonic imaging Veins & arteries Velocity Ventricular Dysfunction, Right - complications Ventricular Dysfunction, Right - diagnostic imaging |
| title | Factors associated with pulmonary hypertension and long-term survival in bronchiectasis subjects |
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