Antimicrobial growth promoter use in livestock: a requirement to understand their modes of action to develop effective alternatives

Highlights • Antimicrobial growth promoters (AGPs) enhance animal health and improve agricultural productivity. • Mechanisms of AGP action are poorly understood; research has diverged into host- and bacteria-centric hypotheses. • Due to risks of antimicrobial resistance, AGPs are being phased out of...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2017-01, Vol.49 (1), p.12-24
Main Authors: Brown, Kirsty, Uwiera, Richard R.E, Kalmokoff, Martin L, Brooks, Steve P.J, Inglis, G. Douglas
Format: Article
Language:English
Subjects:
Alternatives
Animal Husbandry - methods
Animals
Anti-Infective Agents - administration & dosage
Anti-Infective Agents - pharmacology
Antimicrobial agent
Antimicrobial growth promoter
Drug Resistance, Bacterial
Drug Utilization
Gastrointestinal health
Growth Substances - administration & dosage
Growth Substances - pharmacology
Humans
Infectious Disease
Livestock
Livestock agriculture
Mechanisms of action
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Summary:Highlights • Antimicrobial growth promoters (AGPs) enhance animal health and improve agricultural productivity. • Mechanisms of AGP action are poorly understood; research has diverged into host- and bacteria-centric hypotheses. • Due to risks of antimicrobial resistance, AGPs are being phased out of livestock production. • Understanding the mechanisms of AGP action is critical in developing effective non-antibiotic alternatives.
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2016.08.006