Combined cell index in assessing blood donor iron stores

SUMMARY Objectives The aim of this study was to assess the appropriateness of using combined cell index (CCI) in the assessment of iron stores in blood donors. This index is calculated by the formula: red blood cell distribution width (RDW) × 104 × mean corpuscular volume (MCV)−1 × mean corpuscular...

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Bibliographic Details
Published in:Transfusion medicine (Oxford, England) England), 2017-02, Vol.27 (1), p.16-24
Main Authors: Vuk, T., Bingulac‐Popović, J., Očić, T., Mayer, L. J., Milošević, M., Jukić, I.
Format: Article
Language:English
Subjects:
Adult
Blood Donors
combined cell index
Erythrocyte Count
Erythrocyte Indices
Female
ferritin
Ferritins - blood
Humans
Iron - blood
iron stores
Male
Middle Aged
RBC parameters
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Summary:SUMMARY Objectives The aim of this study was to assess the appropriateness of using combined cell index (CCI) in the assessment of iron stores in blood donors. This index is calculated by the formula: red blood cell distribution width (RDW) × 104 × mean corpuscular volume (MCV)−1 × mean corpuscular haemoglobin (MCH)−1. Background Ferritin measurement is a reliable method for estimating iron stores in blood donors. The sensitivity of red blood cell (RBC) parameters of complete blood count in detecting non‐anaemic iron deficiency is significantly lower. Consequently, there were several attempts to increase the detection sensitivity by combining these parameters in different indices. Methods This study included 1084 male and 792 female whole blood donors accepted for blood donation. For six RBC parameters with the highest level of correlation relative to ferritin [Hgb, MCV, MCH, mean corpuscular haemoglobin concentration (MCHC), RDW and CCI], diagnostic efficacy in the detection of iron depletion (ferritin
ISSN:0958-7578
1365-3148
DOI:10.1111/tme.12370