In vitro skin permeation of sinigrin from its phytosome complex

Objectives Sinigrin is a major glucosinolate present in plants of the Brassicaceae family. Recently, sinigrin and its phytosome formulations have been investigated for its wound‐healing actions, by our research group. The aim of this study was to demonstrate sinigrin drug release from its phytosome...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pharmacy and pharmacology 2016-12, Vol.68 (12), p.1577-1583
Main Authors: Mazumder, Anisha, Dwivedi, Anupma, Fox, Lizelle T., Brümmer, Alicia, du Preez, Jan L., Gerber, Minja, du Plessis, Jeanetta
Format: Article
Language:English
Subjects:
Abdomen
Administration, Cutaneous
Delayed-Action Preparations
Diffusion
Drug Carriers
Drug Compounding
Female
Glucosinolates - administration & dosage
Glucosinolates - chemistry
Glucosinolates - metabolism
Humans
In Vitro Techniques
Kinetics
Microscopy, Electron, Transmission
Particle Size
Permeability
Phosphatidylcholines - chemistry
phytosome
sinigrin
sinigrin-phytosome complex
Skin - metabolism
Skin Absorption
skin permeation
Solubility
tape stripping
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives Sinigrin is a major glucosinolate present in plants of the Brassicaceae family. Recently, sinigrin and its phytosome formulations have been investigated for its wound‐healing actions, by our research group. The aim of this study was to demonstrate sinigrin drug release from its phytosome complex and also to determine whether the phytosome complex enhances the delivery of sinigrin into the skin when compared to free sinigrin. Methods In vitro Franz cell diffusion studies were performed on human abdominal skin. The morphology of the phytosome complex was examined by transmission electron microscopy. The in vitro drug release was determined using dialysis sacks. Key findings The in vitro drug release indicated a controlled and sustained release of sinigrin from the phytosome complex. Tape stripping results showed that the sinigrin–phytosome complex (0.5155 μg/ml) statistically significantly enhanced the delivery of sinigrin into the stratum corneum–epidermis when compared to the free sinigrin (0.0730 μg/ml). Conclusions These results suggested the possibility of utilizing sinigrin–phytosome complex, to optimally deliver sinigrin to the skin which can be further used for various skin‐related diseases including wound healing.
ISSN:0022-3573
2042-7158
DOI:10.1111/jphp.12594