Brain Metastasis Prediction by Transcriptomic Profiling in Triple-Negative Breast Cancer

Micro-Abstract We investigated expression of 29,369 gene transcripts in primary tumor samples from 119 patients with advanced triple-negative breast cancer to identify genes with different expression between patients with and without brain metastases (BM). Our results indicate that analysis based on...

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Bibliographic Details
Published in:Clinical breast cancer 2017-04, Vol.17 (2), p.e65-e75
Main Authors: Duchnowska, Renata, Jarząb, Michał, Żebracka-Gala, Jadwiga, Matkowski, Rafał, Kowalczyk, Anna, Radecka, Barbara, Kowalska, Małgorzata, Pfeifer, Aleksandra, Foszczyńska-Kłoda, Małgorzata, Musolino, Antonino, Czartoryska-Arłukowicz, Bogumiła, Litwiniuk, Maria, Surus-Hyla, Anna, Szabłowska-Siwik, Sylwia, Karczmarek-Borowska, Bożenna, Dębska-Szmich, Sylwia, Głodek-Sutek, Beata, Sosińska-Mielcarek, Katarzyna, Chmielowska, Ewa, Kalinka-Warzocha, Ewa, Olszewski, Wojciech P, Patera, Janusz, Żawrocki, Anton, Pliszka, Agnieszka, Tyszkiewicz, Tomasz, Rusinek, Dagmara, Oczko-Wojciechowska, Małgorzata, Jassem, Jacek, Biernat, Wojciech
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - metabolism
Brain metastasis
Brain Neoplasms - diagnosis
Brain Neoplasms - epidemiology
Brain Neoplasms - secondary
cDNA-mediated annealing, extension, and ligation (DASL) assay
Estrogen Receptor alpha - metabolism
Female
Follow-Up Studies
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Hematology, Oncology and Palliative Medicine
Humans
Middle Aged
Neoplasm Staging
Obstetrics and Gynecology
Prognosis
Receptor, ErbB-2 - metabolism
Receptors, Progesterone - metabolism
Retrospective Studies
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - metabolism
Selection
Transcriptomic profiling
Triple negative breast cancer
Triple Negative Breast Neoplasms - genetics
Triple Negative Breast Neoplasms - pathology
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Description
Summary:Micro-Abstract We investigated expression of 29,369 gene transcripts in primary tumor samples from 119 patients with advanced triple-negative breast cancer to identify genes with different expression between patients with and without brain metastases (BM). Our results indicate that analysis based on expression of gene transcripts from primary tumor does not allow prediction of BM development in this population.
ISSN:1526-8209
1938-0666
DOI:10.1016/j.clbc.2016.08.008