Mood disorders and biological rhythms in young adults: A large population-based study

Abstract Background It is known that sleep disturbance has been considered a trait-marker of mood disorders. However, the role of disruptions in biological rhythms, such as eating, activity, and social patterns, needs to be better understood. Aim To assess the differences in biological rhythms in su...

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Bibliographic Details
Published in:Journal of psychiatric research 2017-01, Vol.84, p.98-104
Main Authors: Mondin, Thaíse Campos, Cardoso, Taiane de Azevedo, Souza, Luciano Dias de Mattos, Jansen, Karen, da Silva Magalhães, Pedro Vieira, Kapczinski, Flávio, da Silva, Ricardo Azevedo
Format: Article
Language:English
Subjects:
Adolescent
Biological rhythms
Bipolar disorder
Bipolar Disorder - physiopathology
Circadian preferences
Circadian Rhythm
Cohort Studies
Cross-Sectional Studies
Depressive Disorder, Major - physiopathology
Feeding Behavior
Female
Humans
Interview, Psychological
Major depression
Male
Mood disorders
Motor Activity
Multivariate Analysis
Psychiatric Status Rating Scales
Psychiatry
Regression Analysis
Self Report
Sleep
Social Behavior
Socioeconomic Factors
Young Adult
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Summary:Abstract Background It is known that sleep disturbance has been considered a trait-marker of mood disorders. However, the role of disruptions in biological rhythms, such as eating, activity, and social patterns, needs to be better understood. Aim To assess the differences in biological rhythms in subjects with bipolar disorder, major depressive disorder, and healthy controls. We also tested the association between disruptions of biological rhythms and circadian preferences. Methods A cross-sectional, population-based study with a representative sample of 1023 young adults. Bipolar disorder and depression were diagnosed using The Mini International Neuropsychiatric Interview – PLUS and DSM Structured Clinical Interview. Self-reported biological rhythms and circadian preference were assessed using the Biological Rhythm Interview of Assessment in Neuropsychiatry (BRIAN). Results Bipolar disorders and depression subjects presented higher rates of disruption in biological rhythms when compared to healthy controls even after adjusting for sex, socioeconomic status, alcohol, tobacco, illicit drug use, anxiety disorder and psychotropic medication use. Euthymic subjects showed higher biological rhythm disruption when compared to controls. Higher disruption in biological rhythms was observed in subjects with evening preferences. Conclusion Higher disruption in biological rhythms occurs in individuals with depression and bipolar disorder even on periods of euthymia.
ISSN:0022-3956
1879-1379
DOI:10.1016/j.jpsychires.2016.09.030