Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Relationships of Etravirine in HIV-1-Infected, Treatment-Experienced Children and Adolescents in PIANO

PIANO (NCT00665847) investigated etravirine pharmacokinetics, efficacy, and safety in children and adolescents. Treatment‐experienced, HIV‐1‐infected patients (≥6 to

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Bibliographic Details
Published in:Journal of clinical pharmacology 2016-11, Vol.56 (11), p.1395-1405
Main Authors: Kakuda, Thomas N., Brochot, Anne, Green, Bruce, Nijs, Steven, Vis, Peter, Opsomer, Magda, Tomaka, Frank L., Hoetelmans, Richard M. W.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Child
Drug Administration Schedule
etravirine
Female
HIV Infections - blood
HIV Infections - drug therapy
HIV Protease Inhibitors - administration & dosage
HIV Protease Inhibitors - blood
HIV Protease Inhibitors - pharmacokinetics
HIV-1 - drug effects
HIV/AIDS
Humans
Male
pediatrics
pharmacodynamics
pharmacokinetics
Pyridazines - administration & dosage
Pyridazines - blood
Pyridazines - pharmacokinetics
Reverse Transcriptase Inhibitors - administration & dosage
Reverse Transcriptase Inhibitors - blood
Reverse Transcriptase Inhibitors - pharmacokinetics
Teenagers
Treatment Outcome
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Description
Summary:PIANO (NCT00665847) investigated etravirine pharmacokinetics, efficacy, and safety in children and adolescents. Treatment‐experienced, HIV‐1‐infected patients (≥6 to
ISSN:0091-2700
1552-4604
DOI:10.1002/jcph.746