Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals

Aβ deposition is a driving force of Alzheimer's disease pathology and can be detected early by amyloid positron emission tomography. Identifying presymptomatic structural brain changes associated with Aβ deposition might lead to a better understanding of its consequences and provide early diagn...

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Published in:The European journal of neuroscience 2017-05, Vol.45 (10), p.1241-1251
Main Authors: Schroeder, Clemens, Park, Min Tae M., Germann, Jürgen, Chakravarty, M. Mallar, Michels, Lars, Kollias, Spyros, Kroll, Sara L., Buck, Alfred, Treyer, Valerie, Savaskan, Egemen, Unschuld, Paul G., Nitsch, Roger M., Kälin, Andrea M., Hock, Christoph, Gietl, Anton F., Leh, Sandra E., Foxe, John
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alzheimer's disease
Amyloid beta-Peptides - metabolism
Benzothiazoles
beta‐amyloid
Female
hippocampal shape
Hippocampus - diagnostic imaging
Hippocampus - growth & development
Humans
magnetic resonance imaging
Male
Middle Aged
Positron-Emission Tomography
Radiopharmaceuticals
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Summary:Aβ deposition is a driving force of Alzheimer's disease pathology and can be detected early by amyloid positron emission tomography. Identifying presymptomatic structural brain changes associated with Aβ deposition might lead to a better understanding of its consequences and provide early diagnostic information. In this respect we analyzed measures of cortical thickness and subcortical volumes along with hippocampal, thalamic and striatal shape and surface area by applying novel analysis strategies for structural magnetic resonance imaging. We included 69 cognitively normal elderly subjects after careful clinical and neuropsychological workup. Standardized uptake value ratios (cerebellar reference) for uptake of 11‐C‐Pittsburgh Compound B (PiB) were calculated from positron emission tomographic data for a cortical measurement and for bilateral hippocampus, thalamus and striatum. Associations to shape, surface area, volume and cortical thickness were tested using regression models that included significant predictors as covariates. Left anterior hippocampal shape was associated with regional PiB uptake (P  0.05, FDR corrected). Within the entorhinal cortical region of both hemispheres, thickness was negatively associated with cortical PiB uptake (P 
ISSN:0953-816X
1460-9568
DOI:10.1111/ejn.13408