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Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals
Aβ deposition is a driving force of Alzheimer's disease pathology and can be detected early by amyloid positron emission tomography. Identifying presymptomatic structural brain changes associated with Aβ deposition might lead to a better understanding of its consequences and provide early diagn...
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| Published in: | The European journal of neuroscience 2017-05, Vol.45 (10), p.1241-1251 |
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| creator | Schroeder, Clemens Park, Min Tae M. Germann, Jürgen Chakravarty, M. Mallar Michels, Lars Kollias, Spyros Kroll, Sara L. Buck, Alfred Treyer, Valerie Savaskan, Egemen Unschuld, Paul G. Nitsch, Roger M. Kälin, Andrea M. Hock, Christoph Gietl, Anton F. Leh, Sandra E. Foxe, John |
| description | Aβ deposition is a driving force of Alzheimer's disease pathology and can be detected early by amyloid positron emission tomography. Identifying presymptomatic structural brain changes associated with Aβ deposition might lead to a better understanding of its consequences and provide early diagnostic information. In this respect we analyzed measures of cortical thickness and subcortical volumes along with hippocampal, thalamic and striatal shape and surface area by applying novel analysis strategies for structural magnetic resonance imaging. We included 69 cognitively normal elderly subjects after careful clinical and neuropsychological workup. Standardized uptake value ratios (cerebellar reference) for uptake of 11‐C‐Pittsburgh Compound B (PiB) were calculated from positron emission tomographic data for a cortical measurement and for bilateral hippocampus, thalamus and striatum. Associations to shape, surface area, volume and cortical thickness were tested using regression models that included significant predictors as covariates. Left anterior hippocampal shape was associated with regional PiB uptake (P 0.05, FDR corrected). Within the entorhinal cortical region of both hemispheres, thickness was negatively associated with cortical PiB uptake (P |
| doi_str_mv | 10.1111/ejn.13408 |
| format | article |
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The authors of this study report a significant association between left hippocampal shape and amyloid deposition measured by PiB‐PET in this region in a sample of cognitively healthy elderly individuals. This result was paralleled by a negative association between cortical amyloid burden and thickness of the entorhinal cortex, which is part of the cortical signature of AD. The results of this study show that measurements of entorhinal cortical thickness and hippocampal shape are capable to identify early structural brain changes that occur in association with regional or cortical amyloid deposition in presymptomatic AD.</description><identifier>ISSN: 0953-816X</identifier><identifier>EISSN: 1460-9568</identifier><identifier>DOI: 10.1111/ejn.13408</identifier><identifier>PMID: 27646656</identifier><language>eng</language><publisher>France</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer's disease ; Amyloid beta-Peptides - metabolism ; Benzothiazoles ; beta‐amyloid ; Female ; hippocampal shape ; Hippocampus - diagnostic imaging ; Hippocampus - growth & development ; Humans ; magnetic resonance imaging ; Male ; Middle Aged ; Positron-Emission Tomography ; Radiopharmaceuticals</subject><ispartof>The European journal of neuroscience, 2017-05, Vol.45 (10), p.1241-1251</ispartof><rights>2016 Federation of European Neuroscience Societies and John Wiley & Sons Ltd</rights><rights>2016 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3608-389d9cba8a692bb5bbc0a755988dd2ea5c2c2e946b53b6c9a287cfa74219c7053</citedby><cites>FETCH-LOGICAL-c3608-389d9cba8a692bb5bbc0a755988dd2ea5c2c2e946b53b6c9a287cfa74219c7053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27646656$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Foxe, John</contributor><creatorcontrib>Schroeder, Clemens</creatorcontrib><creatorcontrib>Park, Min Tae M.</creatorcontrib><creatorcontrib>Germann, Jürgen</creatorcontrib><creatorcontrib>Chakravarty, M. Mallar</creatorcontrib><creatorcontrib>Michels, Lars</creatorcontrib><creatorcontrib>Kollias, Spyros</creatorcontrib><creatorcontrib>Kroll, Sara L.</creatorcontrib><creatorcontrib>Buck, Alfred</creatorcontrib><creatorcontrib>Treyer, Valerie</creatorcontrib><creatorcontrib>Savaskan, Egemen</creatorcontrib><creatorcontrib>Unschuld, Paul G.</creatorcontrib><creatorcontrib>Nitsch, Roger M.</creatorcontrib><creatorcontrib>Kälin, Andrea M.</creatorcontrib><creatorcontrib>Hock, Christoph</creatorcontrib><creatorcontrib>Gietl, Anton F.</creatorcontrib><creatorcontrib>Leh, Sandra E.</creatorcontrib><creatorcontrib>Foxe, John</creatorcontrib><title>Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals</title><title>The European journal of neuroscience</title><addtitle>Eur J Neurosci</addtitle><description>Aβ deposition is a driving force of Alzheimer's disease pathology and can be detected early by amyloid positron emission tomography. Identifying presymptomatic structural brain changes associated with Aβ deposition might lead to a better understanding of its consequences and provide early diagnostic information. In this respect we analyzed measures of cortical thickness and subcortical volumes along with hippocampal, thalamic and striatal shape and surface area by applying novel analysis strategies for structural magnetic resonance imaging. We included 69 cognitively normal elderly subjects after careful clinical and neuropsychological workup. Standardized uptake value ratios (cerebellar reference) for uptake of 11‐C‐Pittsburgh Compound B (PiB) were calculated from positron emission tomographic data for a cortical measurement and for bilateral hippocampus, thalamus and striatum. Associations to shape, surface area, volume and cortical thickness were tested using regression models that included significant predictors as covariates. Left anterior hippocampal shape was associated with regional PiB uptake (P < 0.05, FDR corrected), whereas volumes of the hippocampi and their subregions were not associated with cortical or regional PiB uptake (all P > 0.05, FDR corrected). Within the entorhinal cortical region of both hemispheres, thickness was negatively associated with cortical PiB uptake (P < 0.05, FDR corrected). Hence, localized shape measures and cortical thickness may be potential biomarkers of presymptomatic Alzheimer's disease.
The authors of this study report a significant association between left hippocampal shape and amyloid deposition measured by PiB‐PET in this region in a sample of cognitively healthy elderly individuals. This result was paralleled by a negative association between cortical amyloid burden and thickness of the entorhinal cortex, which is part of the cortical signature of AD. The results of this study show that measurements of entorhinal cortical thickness and hippocampal shape are capable to identify early structural brain changes that occur in association with regional or cortical amyloid deposition in presymptomatic AD.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer's disease</subject><subject>Amyloid beta-Peptides - metabolism</subject><subject>Benzothiazoles</subject><subject>beta‐amyloid</subject><subject>Female</subject><subject>hippocampal shape</subject><subject>Hippocampus - diagnostic imaging</subject><subject>Hippocampus - growth & development</subject><subject>Humans</subject><subject>magnetic resonance imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Positron-Emission Tomography</subject><subject>Radiopharmaceuticals</subject><issn>0953-816X</issn><issn>1460-9568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kMFO3DAURa2KqjNMu-AHkJewCDhx7NhLhKC0Qu2mlbqLXuw3Mx45cbAzoPmtfgjfhMsM7Po2V0_36CwuIScluyjzXeJmuCh5zdQHMi9ryQotpDoic6YFL1Qp_8zIcUobxpiStfhEZlUjaymFnJP-zo1jMNCP4Glaw4gU_IQRJheGRCHmP6VgHExo6ZOb1jTiKncZv3r-S30AS91ATVgNbnKP6Hd0CLHPNXqLMb9usO7R2S349Jl8XObAL4dckN-3N7-u74r7n1-_XV_dF4ZLpgqutNWmAwVSV10nus4waITQSllbIQhTmQp1LTvBO2k0VKoxS2jqqtSmYYIvyNneO8bwsMU0tb1LBr2HAcM2taXigmuuXtHzPWpiSCnish2j6yHu2pK1_9Zt87rt67qZPT1ot12P9p18mzMDl3vgyXnc_d_U3nz_sVe-APuNhsg</recordid><startdate>201705</startdate><enddate>201705</enddate><creator>Schroeder, Clemens</creator><creator>Park, Min Tae M.</creator><creator>Germann, Jürgen</creator><creator>Chakravarty, M. Mallar</creator><creator>Michels, Lars</creator><creator>Kollias, Spyros</creator><creator>Kroll, Sara L.</creator><creator>Buck, Alfred</creator><creator>Treyer, Valerie</creator><creator>Savaskan, Egemen</creator><creator>Unschuld, Paul G.</creator><creator>Nitsch, Roger M.</creator><creator>Kälin, Andrea M.</creator><creator>Hock, Christoph</creator><creator>Gietl, Anton F.</creator><creator>Leh, Sandra E.</creator><creator>Foxe, John</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201705</creationdate><title>Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals</title><author>Schroeder, Clemens ; Park, Min Tae M. ; Germann, Jürgen ; Chakravarty, M. Mallar ; Michels, Lars ; Kollias, Spyros ; Kroll, Sara L. ; Buck, Alfred ; Treyer, Valerie ; Savaskan, Egemen ; Unschuld, Paul G. ; Nitsch, Roger M. ; Kälin, Andrea M. ; Hock, Christoph ; Gietl, Anton F. ; Leh, Sandra E. ; Foxe, John</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3608-389d9cba8a692bb5bbc0a755988dd2ea5c2c2e946b53b6c9a287cfa74219c7053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer's disease</topic><topic>Amyloid beta-Peptides - metabolism</topic><topic>Benzothiazoles</topic><topic>beta‐amyloid</topic><topic>Female</topic><topic>hippocampal shape</topic><topic>Hippocampus - diagnostic imaging</topic><topic>Hippocampus - growth & development</topic><topic>Humans</topic><topic>magnetic resonance imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Positron-Emission Tomography</topic><topic>Radiopharmaceuticals</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schroeder, Clemens</creatorcontrib><creatorcontrib>Park, Min Tae M.</creatorcontrib><creatorcontrib>Germann, Jürgen</creatorcontrib><creatorcontrib>Chakravarty, M. 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Mallar</au><au>Michels, Lars</au><au>Kollias, Spyros</au><au>Kroll, Sara L.</au><au>Buck, Alfred</au><au>Treyer, Valerie</au><au>Savaskan, Egemen</au><au>Unschuld, Paul G.</au><au>Nitsch, Roger M.</au><au>Kälin, Andrea M.</au><au>Hock, Christoph</au><au>Gietl, Anton F.</au><au>Leh, Sandra E.</au><au>Foxe, John</au><au>Foxe, John</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals</atitle><jtitle>The European journal of neuroscience</jtitle><addtitle>Eur J Neurosci</addtitle><date>2017-05</date><risdate>2017</risdate><volume>45</volume><issue>10</issue><spage>1241</spage><epage>1251</epage><pages>1241-1251</pages><issn>0953-816X</issn><eissn>1460-9568</eissn><abstract>Aβ deposition is a driving force of Alzheimer's disease pathology and can be detected early by amyloid positron emission tomography. Identifying presymptomatic structural brain changes associated with Aβ deposition might lead to a better understanding of its consequences and provide early diagnostic information. In this respect we analyzed measures of cortical thickness and subcortical volumes along with hippocampal, thalamic and striatal shape and surface area by applying novel analysis strategies for structural magnetic resonance imaging. We included 69 cognitively normal elderly subjects after careful clinical and neuropsychological workup. Standardized uptake value ratios (cerebellar reference) for uptake of 11‐C‐Pittsburgh Compound B (PiB) were calculated from positron emission tomographic data for a cortical measurement and for bilateral hippocampus, thalamus and striatum. Associations to shape, surface area, volume and cortical thickness were tested using regression models that included significant predictors as covariates. Left anterior hippocampal shape was associated with regional PiB uptake (P < 0.05, FDR corrected), whereas volumes of the hippocampi and their subregions were not associated with cortical or regional PiB uptake (all P > 0.05, FDR corrected). Within the entorhinal cortical region of both hemispheres, thickness was negatively associated with cortical PiB uptake (P < 0.05, FDR corrected). Hence, localized shape measures and cortical thickness may be potential biomarkers of presymptomatic Alzheimer's disease.
The authors of this study report a significant association between left hippocampal shape and amyloid deposition measured by PiB‐PET in this region in a sample of cognitively healthy elderly individuals. This result was paralleled by a negative association between cortical amyloid burden and thickness of the entorhinal cortex, which is part of the cortical signature of AD. The results of this study show that measurements of entorhinal cortical thickness and hippocampal shape are capable to identify early structural brain changes that occur in association with regional or cortical amyloid deposition in presymptomatic AD.</abstract><cop>France</cop><pmid>27646656</pmid><doi>10.1111/ejn.13408</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Alzheimer's disease Amyloid beta-Peptides - metabolism Benzothiazoles beta‐amyloid Female hippocampal shape Hippocampus - diagnostic imaging Hippocampus - growth & development Humans magnetic resonance imaging Male Middle Aged Positron-Emission Tomography Radiopharmaceuticals |
| title | Hippocampal shape alterations are associated with regional Aβ load in cognitively normal elderly individuals |
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