Aggressive esthesioneuroblastoma with divergent differentiation: A taxonomic dilemma

The authors describe an esthesioneuroblastoma (olfactory neuroblastoma) that occurred within the nasal cavity and brain in a 31-year-old man. Following excision, the tumor recurred in the left orbit and in mediastinal lymph nodes. Treatment included orbital excision and systemic chemotherapy. Histop...

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Bibliographic Details
Published in:Orbit (Amsterdam) 2016-12, Vol.35 (6), p.357-359
Main Authors: Charles, Norman C, Petris, Carisa K, Kim, Eleanore T
Format: Article
Language:English
Subjects:
Adult
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biomarkers, Tumor - metabolism
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - pathology
Brain Neoplasms - therapy
Esthesioneuroblastoma, Olfactory - diagnostic imaging
Esthesioneuroblastoma, Olfactory - secondary
Esthesioneuroblastoma, Olfactory - therapy
Humans
Lymphatic Metastasis
Magnetic Resonance Imaging
Male
Mediastinum
Nasal Cavity
Neoplasm Recurrence, Local - pathology
Nose Neoplasms - diagnostic imaging
Nose Neoplasms - pathology
Nose Neoplasms - therapy
Orbital Neoplasms - diagnostic imaging
Orbital Neoplasms - secondary
Orbital Neoplasms - therapy
Tomography, X-Ray Computed
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Summary:The authors describe an esthesioneuroblastoma (olfactory neuroblastoma) that occurred within the nasal cavity and brain in a 31-year-old man. Following excision, the tumor recurred in the left orbit and in mediastinal lymph nodes. Treatment included orbital excision and systemic chemotherapy. Histopathology showed a high-grade neuroepithelial tumor with positive immunohistochemical markers for neuroendocrine and epithelial components, an unusual combination raising issues concerning taxonomy.
ISSN:0167-6830
1744-5108
DOI:10.1080/01676830.2016.1193537