Biomarkers of Morbid Obesity and Prediabetes by Metabolomic Profiling of Human Discordant Phenotypes

• Published in: Clinica chimica acta 2016-12, Vol.463, p.53-61
• Main Authors: Tulipani, Sara, Palau-Rodriguez, Magali, Miñarro Alonso, Antonio, Cardona, Fernando, Marco-Ramell, Anna, Zonja, Bozo, Lopez de Alda, Miren, Muñoz-Garach, Araceli, Sanchez-Pla, Alejandro, Tinahones, Francisco J, Andres-Lacueva, Cristina
• Format: Article
• Language: English
• Subjects: Adult; Biomarkers - blood; Biomarkers - metabolism; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - metabolism; Female; Humans; Male; mass spectrometry; metabolic markers; Metabolomics; Middle Aged; obesity; Obesity, Morbid - blood; Obesity, Morbid - diagnosis; Obesity, Morbid - metabolism; observational study; Phenotype; prediabetes; Prediabetic State - blood; Prediabetic State - diagnosis; Prediabetic State - metabolism
• ISSN: 0009-8981; 1873-3492
• DOI: 10.1016/j.cca.2016.10.005

Metabolomic studies aimed to dissect the connection between the development of type 2 diabetes and obesity are still scarce. In the present study, fasting serum from sixty-four adult individuals classified into four sex-matched groups by their BMI [non-obese versus morbid obese] and the increased risk of developing diabetes [prediabetic insulin resistant state versus non-prediabetic non-insulin resistant] was analyzed by LC- and FIA-ESI-MS/MS–driven metabolomic approaches. Altered levels of [lyso]glycerophospholipids was the most specific metabolic trait associated to morbid obesity, particularly lysophosphatidylcholines acylated with margaric, oleic and linoleic acids [lysoPC C17:0: R=−0.56, p=0.0003; lysoPC C18:1: R=−0.61, p=0.0001; lysoPC C18:2 R=−0.64, p