miR‐296 inhibits proliferation and induces apoptosis by targeting FGFR1 in human hepatocellular carcinoma

MiR‐296 was previously reported to be underexpressed in hepatocellular carcinoma (HCC). However, the clinical value of miR‐296 and its function in HCC remain poorly understood. In this study, we found that miR‐296 levels are decreased in HCC specimens and cells, and that the underexpression of miR‐2...

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Bibliographic Details
Published in:FEBS letters 2016-12, Vol.590 (23), p.4252-4262
Main Authors: Wang, Liyan, Bo, Xiaotong, Zheng, Qinghua, Xiao, Xuhua, Wu, Linling, Li, Bin
Format: Article
Language:English
Subjects:
apoptosis
Apoptosis - genetics
Base Sequence
Carcinoma, Hepatocellular - diagnosis
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - pathology
cell cycle
Cell Cycle - genetics
Cell Line, Tumor
cell proliferation
Cell Proliferation - genetics
Female
FGFR1
hepatocellular carcinoma
Humans
Liver Neoplasms - diagnosis
Liver Neoplasms - genetics
Liver Neoplasms - pathology
Male
MicroRNAs - genetics
Middle Aged
miR‐296
Prognosis
Receptor, Fibroblast Growth Factor, Type 1 - genetics
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Summary:MiR‐296 was previously reported to be underexpressed in hepatocellular carcinoma (HCC). However, the clinical value of miR‐296 and its function in HCC remain poorly understood. In this study, we found that miR‐296 levels are decreased in HCC specimens and cells, and that the underexpression of miR‐296 is associated with adverse clinical parameters and poor overall survival rate. In vitro experiments indicate that miR‐296 inhibits proliferation, colony formation, and cell cycle progression, and enhances apoptosis in HCC cells. Notably, we found that the fibroblast growth factor receptor 1 (FGFR1) is a downstream target that mediates the functions of miR‐296 in HCC. Thus, our findings indicate that miR‐296 exerts a tumor suppressive role in HCC and is a potential biomarker and drug‐target.
ISSN:0014-5793
1873-3468
DOI:10.1002/1873-3468.12442