Different contribution of glucocorticoids in the basolateral amygdala to the formation and expression of opiate withdrawal-associated memories

Highlights • ADX morphine dependent rats do not exhibit naloxone-induced conditioned place aversion. • However, adrenalectomy increases the somatic expression of opiate withdrawal. • GR expression correlated with pCREB, Egr-1 and Arc induction only in sham-dependent rats during the consolidation pro...

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Bibliographic Details
Published in:Psychoneuroendocrinology 2016-12, Vol.74, p.350-362
Main Authors: García-Pérez, Daniel, Ferenczi, Szilamer, Kovács, Krisztina J, Laorden, M. Luisa, Milanés, M. Victoria, Núñez, Cristina
Format: Article
Language:English
Subjects:
Adrenalectomy
Animals
Basolateral Nuclear Complex - metabolism
Conditioned place aversion
Conditioning, Classical
Endocrinology & Metabolism
Glucocorticoids - metabolism
Male
Memory Consolidation - physiology
Memory consolidation and retrieval
Mental Recall - physiology
miRNAs
Morphine dependence
Morphine Dependence - metabolism
Psychiatry
Rats
Rats, Wistar
Receptors, Glucocorticoid - metabolism
Signal Transduction - physiology
Substance Withdrawal Syndrome - metabolism
Transcription factors
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Summary:Highlights • ADX morphine dependent rats do not exhibit naloxone-induced conditioned place aversion. • However, adrenalectomy increases the somatic expression of opiate withdrawal. • GR expression correlated with pCREB, Egr-1 and Arc induction only in sham-dependent rats during the consolidation process. • Memory retrieval enhanced Arc levels in sham + morphine, but not in ADX + morphine animals.
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2016.09.020