Susceptibility of Candida albicans Isolated from Blood to Wickerhamomyces anomalous Mycocins

• Published in: Current microbiology 2016-12, Vol.73 (6), p.878-884
• Main Authors: Paris, Ana Paula, Persel, Cristiane, Serafin, Cleber Fernando, de Cássia Garcia Simão, Rita, Gandra, Rinaldo Ferreira
• Format: Article
• Language: English
• Subjects: Antifungal activity; Antifungal Agents - metabolism; Antifungal Agents - pharmacology; Biomedical and Life Sciences; Biotechnology; Blood; Blood - microbiology; Candida albicans - classification; Candida albicans - drug effects; Candida albicans - genetics; Candida albicans - isolation & purification; Candidiasis - blood; Candidiasis - microbiology; Cell Wall - chemistry; Cell Wall - metabolism; Cell walls; Developing countries; Drug therapy; Fungi; Fungicides; Hemolysis; Humans; LDCs; Life Sciences; Microbial Sensitivity Tests; Microbiology; Mushrooms; Plant diseases; Plant resistance; Saccharomycetales - chemistry; Saccharomycetales - genetics; Saccharomycetales - isolation & purification; Saccharomycetales - metabolism; Soil Microbiology; Yeast; Yeasts
• ISSN: 0343-8651; 1432-0991
• DOI: 10.1007/s00284-016-1135-4

The occurrence of infections caused by Candida albicans in developed and developing countries and their resistance to some available antifungal drugs have been viewed as causing a great problem to human health worldwide. In order to find new researched molecules, there are some mycoses secreted by yeasts, especially mycocins produced by Wickerhamomyces anomalus with a broad antimicrobial spectrum of activity. Thus, this trial aimed at evaluating mycocins’ activity obtained from environmental W. anomalus cell wall compared to thirty C. albicans strains isolated from blood. Mycocins were extracted from cell walls of three W. anomalus strains (WA40, WA45, and WA92). The 400 μg mL −1 concentration of WA40M1, WA45M2, and WA92M3 mycocin extracts showed the following respective activity results: 96.6, 96.6, and 90.0 % C. albicans strains. WA45M2 and WA92M3 mycocin extracts showed some activity in 3.3 % of C. albicans strains at 50 μg mL −1 concentration. Mycocins extracted from cell walls of three W. anomalus strains named as WA40, WA45, and WA92 showed antifungal activity compared to C. albicans and low degree of hemolysis.