Can surgical need in patients with Naja atra (Taiwan or Chinese cobra) envenomation be predicted in the emergency department?

• Published in: Hong Kong medical journal = Xianggang yi xue za zhi 2016-10, Vol.22 (5), p.435-444
• Main Authors: Su, H Y, Wang, M J, Li, Y H, Tang, C N, Tsai, M J
• Format: Article
• Language: English
• Subjects: Animals; Anti-Bacterial Agents - administration & dosage; Antivenins - administration & dosage; Bacterial Infections - epidemiology; Bacterial Infections - microbiology; Ecchymosis - epidemiology; Ecchymosis - etiology; Ecchymosis - surgery; Elapid Venoms - toxicity; Emergency Service, Hospital; Fasciitis, Necrotizing - epidemiology; Fasciitis, Necrotizing - etiology; Fasciitis, Necrotizing - surgery; Female; Humans; Male; Middle Aged; Naja naja; Retrospective Studies; Snake Bites - complications; Snake Bites - surgery; Snake Bites - therapy; Taiwan
• ISSN: 1024-2708
• DOI: 10.12809/hkmj154739

To investigate the clinical predictors and the aetiologies for surgery in patients with (Taiwan or Chinese cobra) envenomation. This case series was conducted in the only tertiary care centre in eastern Taiwan. Patients who presented to the emergency department with bite between January 2008 and September 2014 were included. Clinical information was collected and compared between surgical and non-surgical patients. A total of 28 patients with envenomation presented to the emergency department during the study period. Of these, 60.7% (n=17) required surgery. Necrotising fasciitis (76.5%) was the main finding in surgery. Comparisons between surgical and non-surgical patients showed skin ecchymosis (odds ratio=34.36; 95% confidence interval, 2.20-536.08; P=0.012) and a high total dose of antivenin (≥6 vials; odds ratio=14.59; 95% confidence interval, 1.10-192.72; P=0.042) to be the most significant predictors of surgery. The rate of bacterial isolation from the surgical wound was 88.2%. (76.5%), (58.8%), and (29.4%) were the most common pathogens involved. Bacterial susceptibility testing indicated that combined broad-spectrum antibiotics were needed to cover mixed aerobic and anaerobic bacterial infection. Patients with envenomation who present with skin ecchymosis or the need for a high dose of antivenin may require early surgical assessment. Combined broad-spectrum antibiotics are mandatory.